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Assoz. Prof. Mag. Dr. Christian Kowol

T: +43-1-4277-52611

christian.kowol@univie.ac.at

http://anorg-chemie.univie.ac.at/research/bioinorganic-chemistry/group-christian-kowol/

Summer term 2023

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270186 PR Practical Course Coordination Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

Winter term 2022

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270029 PR Basic Chemistry Laboratory Course I - Preparative Lab Course

270186 PR Practical Course Coordination Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

270314 VO Bioinorganic Chemistry

Summer term 2022

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270023 UE Inorganic Chemistry Lab course D - Inorganic Chemistry Lab course IIID - Coordination chemistry

270029 PR STEOP: Basic Chemistry Laboratory Course I - Preparative Lab Course

270100 UE Inorganic Chemistry Lab course A - Inorganic Chemistry Lab course III A - Bioinorganic Chemistry, coordination chemistry

Mendrina, T., Poetsch, I., Schueffl, H., Baier, D., Pirker, C., Ries, A., Keppler, B. K., Kowol, C. R., Gibson, D., Grusch, M., Berger, W., & Heffeter, P. (2023). Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands. Pharmaceutics, 15(2), [677]. https://doi.org/10.3390/pharmaceutics15020677

Strasser, P., Montsch, B., Weiss, S., Sami, H., Kugler, C., Hager, S., Schueffl, H., Mader, R., Brüggemann, O., Kowol, C. R., Ogris, M., Heffeter, P., & Teasdale, I. (2023). Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo. Small. https://doi.org/10.1002/smll.202300767

Liu, X., Barth, M-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Keppler, B. K., Gibson, D., & Weigand, W. (2022). Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity. Chemistry & Biodiversity, 19(10), [e202200695]. https://doi.org/10.1002/cbdv.202200695

Liu, X., Wenisch, D., Barth, M-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Gibson, D., Keppler, B. K., & Weigand, W. (2022). Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions, 51(44), 16824-16835. https://doi.org/10.1039/d2dt02217f

Schwendenwein, A., Boettiger, K., Kovacs, I., Barany, N., Megyesfalvi, Z., Grusch, M., Kowol, C., Rezeli, M., Hoetzenecker, K., Dome, B., & Schelch, K. (2022). EP14.02-00 Cisplatin in Combination with Entinostat exerts Synergistic Antineoplastic Activity in Small Cell Lung Cancer. Journal of thoracic oncology, 17(9), S537-S537.

Posa, V., Stefanelli, A., Nunes, J. H. B., Hager, S., Mathuber, M., May, N., Berger, W., Keppler, B. K., Kowol, C. R., Enyedy, E. A., & Heffeter, P. (2022). Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance. Cancers, 14(18), [4455]. https://doi.org/10.3390/cancers14184455

Falcone, E., Ritacca, A. G., Hager, S., Schueffl, H., Vileno, B., El Khoury, Y., Hellwig, P., Kowol, C. R., Heffeter, P., Sicilia, E., & Faller, P. (2022). Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH. Journal of the American Chemical Society, 144(32), 14758-14768. https://doi.org/10.1021/jacs.2c05355

Posa, V., Hajdu, B., Toth, G., Domotor, O., Kowol, C. R., Keppler, B. K., Spengler, G., Gyurcsik, B., & Enyedy, E. A. (2022). The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity. Journal of Inorganic Biochemistry, 231, [111786]. https://doi.org/10.1016/j.jinorgbio.2022.111786

Fronik, P., Gutmann, M., Vician, P., Stojanovic, M., Kastner, A., Heffeter, P., Pirker, C., Keppler, B. K., Berger, W., & Kowol, C. R. (2022). A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance. Communications Chemistry, 5(1), [46]. https://doi.org/10.1038/s42004-022-00661-z

Kandioller, W., Theiner, J., Keppler, B. K., & Kowol, C. R. (2021). Elemental analysis: an important purity control but prone to manipulations. Inorganic Chemistry Frontiers, 9(3), 412-416. https://doi.org/10.1039/d1qi01379c

Terenzi, A., La Franca, M., van Schoonhoven, S., Panchuk, R., Martinez, A., Heffeter, P., Gober, R., Pirker, C., Vician, P., Kowol, C. R., Stoika, R., Salassa, L., Rohr, J., & Berger, W. (2021). Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism. Communications Chemistry, 4(1), [162]. https://doi.org/10.1038/s42004-021-00600-4

Schueffl, H., Theiner, S., Hermann, G., Mayr, J., Fronik, P., Groza, D., van Schonhooven, S., Galvez, L., Sommerfeld, N. S., Schintlmeister, A., Reipert, S., Wagner, M., Mader, R. M., Koellensperger, G., Keppler, B. K., Berger, W., Kowol, C. R., Legin, A., & Heffeter, P. (2021). Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo. Chemical Science, 12(38), 12587-12599. https://doi.org/10.1039/D1SC03311E

Mathuber, M., Hager, S., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2021). Liposomal formulations of anticancer copper(ii) thiosemicarbazone complexes. Dalton Transactions, 50(44), 16053-16066. https://doi.org/10.1039/d1dt02763h

Fronik, P., Poetsch, I., Kastner, A., Mendrina, T., Hager, S., Hohenwallner, K., Schueffl, H., Herndler-Brandstetter, D., Koellensperger, G., Rampler, E., Kopecka, J., Riganti, C., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2021). Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands. Journal of Medicinal Chemistry, 64(16), 12132-12151. https://doi.org/10.1021/acs.jmedchem.1c00770

Mathuber, M., Gutmann, M., La Franca, M., Vician, P., Laemmerer, A., Moser, P., Keppler, B. K., Berger, W., & Kowol, C. R. (2021). Development of a cobalt(iii)-based ponatinib prodrug system. Inorganic Chemistry Frontiers, 8(10), 2468-2485. https://doi.org/10.1039/d1qi00211b

Enyedy, É. A., May, N. V., Pape, V. F. S., Heffeter, P., Szakács, G., Keppler, B. K., & Kowol, C. R. (2020). Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Transactions, 49(46), 16887-16902. https://doi.org/10.1039/d0dt03465g

Mathuber, M., Schueffl, H., Dömötör, O., Karnthaler, C., Enyedy, É. A., Heffeter, P., Keppler, B. K., & Kowol, C. R. (2020). Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs. Inorganic Chemistry, 59(23), 17794-17810 . https://doi.org/10.1021/acs.inorgchem.0c03083

Lahnsteiner, M., Kastner, A., Mayr, J., Roller, A., Keppler, B. K., & Kowol, C. R. (2020). Improving the Stability of Maleimide-Thiol Conjugation for Drug Targeting. Chemistry: A European Journal, 26(68), 15867-15870. https://doi.org/10.1002/chem.202003951

Bormio Nunes, J. H., Hager, S., Mathuber, M., Pósa, V., Roller, A., Enyedy, E. A., Stefanelli, A., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2020). Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux. Journal of Medicinal Chemistry, 63(22), 13719-13732. https://doi.org/10.1021/acs.jmedchem.0c01277

Hager, S., Pape, V. F. S., Posa, V., Montsch, B., Uhlik, L., Szakacs, G., Toth, S., Jabronka, N., Keppler, B. K., Kowol, C. R., Enyedy, E. A., & Heffeter, P. (2020). High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones. Antioxidants and Redox Signaling, 33(6), 395-414. https://doi.org/10.1089/ars.2019.7854