Assoz. Prof. Dipl.-Ing. Markus Muttenthaler, PhD
Markus Muttenthaler
Summer term 2023
270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry
Winter term 2022
270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry
270295 VU Chemical Biology
Summer term 2022
270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry
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Kremsmayr, T., Aljnabi, A., Blanco-Canosa, J. B., Tran, H. N. T., Emidio, N. B., & Muttenthaler, M. (2022). On the Utility of Chemical Strategies to Improve Peptide Gut Stability. Journal of Medicinal Chemistry, 65(8), 6191-6206. https://doi.org/10.1021/acs.jmedchem.2c00094

Kremsmayr, T., & Muttenthaler, M. (2022). Fmoc Solid Phase Peptide Synthesis of Oxytocin and Analogues. In E. L. Werry, T. A. Reekie, & M. Kassiou (Eds.), Oxytocin: Methods and Protocols (1 ed., Vol. 2384, pp. 175-199). Humana Press, Springer. Methods in Molecular Biology Vol. 2384 https://doi.org/10.1007/978-1-0716-1759-5_11

Baumgartner, M., Lang, M., Holley, H., Crepaz, D., Hausmann, B., Pjevac, P., Moser, D., Haller, F., Hof, F., Beer, A., Orgler, E., Frick, A., Khare, V., Evstatiev, R., Strohmaier, S., Primas, C., Dolak, W., Köcher, T., Klavins, K., ... Gasche, C. (2021). Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Gastroenterology, 161(4), 1245-1256. https://doi.org/10.1053/j.gastro.2021.06.024

Emidio, N. B., Meli, R., Tran, H. N. T., Baik, H., Morisset-Lopez, S., Elliott, A. G., Blaskovich, M. A. T., Spiller, S., Beck-Sickinger, A. G., Schroeder, C. I., & Muttenthaler, M. (2021). Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite. Journal of Medicinal Chemistry, 64(13), 9484-9495. https://doi.org/10.1021/acs.jmedchem.1c00767

Emidio, N. B., Tran, H. N. T., Andersson, A., Dawson, P. E., Albericio, F., Vetter, I., & Muttenthaler, M. (2021). Improving the Gastrointestinal Stability of Linaclotide. Journal of Medicinal Chemistry, 64(12), 8384-8390. https://doi.org/10.1021/acs.jmedchem.1c00380


Dekan, Z., Kremsmayr, T., Keov, P., Godin, M., Teakle, N., Durrauer, L., Xiang, H., Gharib, D., Bergmayr, C., Hellinger, R., Gay, M., Vilaseca, M., Kurzbach, D., Albericio, F., Alewood, P. F., Gruber, C. W., & Muttenthaler, M. (2021). Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin. Chemical Science, 12(11), 4057-4062. https://doi.org/10.1039/d0sc05501h




Touchard, A., Mendel, H. C., Boulogne, I., Herzig, V., Braga Emidio, N., King, G. F., Triquigneaux, M., Jaquillard, L., Beroud, R., De Waard, M., Delalande, O., Dejean, A., Muttenthaler, M., & Duplais, C. (2020). Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms. ACS Pharmacology and Translational Science, 3(6), 1211–1224. https://doi.org/10.1021/acsptsci.0c00119



Braga Emidio, N., Baik, H., Lee, D., Stuermer, R., Heuer, J., Elliott, A. G., Blaskovich, M. A. T., Haupenthal, K., Tegtmeyer, N., Hoffmann, W., Schroeder, C. I., & Muttenthaler, M. (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action (vol 75, pg 5602, 2020). Chemical Communications, 56(51), 7049-7049. https://doi.org/10.1039/d0cc90250k

Emidio, N. B., Baik, H., Lee, D., Stuermer, R., Heuer, J., Elliott, A. G., Blaskovich, M. A. T., Haupenthal, K., Tegtmeyer, N., Hoffmann, W., Schroeder, C., & Muttenthaler, M. (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56(47), 6420-6423. https://doi.org/10.1039/d0cc02321c


Jadhav, K. B., Woolcock, K. J., & Muttenthaler, M. (2020). Anhydrous hydrogen fluoride cleavage in boc solid phase peptide synthesis. In W. M. Hussein, M. Skwarczynski, & I. Toth (Eds.), Peptide Synthesis: Methods and Protocols (Vol. 2103, pp. 41-57). Humana Press, Springer. Methods in Molecular Biology https://doi.org/10.1007/978-1-0716-0227-0_4

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Fluorescent peptide tracers for oxytocin receptor visualization

Monika Perisic (Speaker), Predrag Kalaba (Contributor), C.W. Gruber (Contributor) & Markus Muttenthaler (Contributor)

1 Dec 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Gut-specific peptide therapeutics

Markus Muttenthaler (Speaker)

13 Nov 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Gut-stable peptide therapeutics

Markus Muttenthaler (Speaker)

28 Aug 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Molecular strategies to tune venom peptide functionality

Markus Muttenthaler (Keynote speaker)

7 Aug 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Gut-specific peptide therapeutics

Markus Muttenthaler (Invited speaker)

4 Aug 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


From Venoms to Neuropeptides – Molecular Tools for Neuroscience

Markus Muttenthaler (Invited speaker)

16 Jun 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Gut-specific peptide therapeutics

Markus Muttenthaler (Keynote speaker)

29 May 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Molecular strategies to study and treat gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

17 May 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Molecular strategies to study and treat gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

15 May 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Biologically active oxytocin probes allow (sub)-cellular receptor localization

Monika Perisic (Speaker), Predrag Kalaba (Contributor), Erik Keimpema (Contributor), Thomas Kremsmayr (Contributor), Satish Dighe (Contributor), Christian Gruber (Contributor), Katsuhiko Nishimori (Contributor) & Markus Muttenthaler (Contributor)

12 May 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Chemical strategies to tune potency, selectivity and stability of neuropeptides

Markus Muttenthaler (Speaker)

4 Oct 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploring natural scaffolds to engineer gut-stable peptide ligands

Thomas Kremsmayr (Speaker), Christian Friedrich Wilhelm Becker (Contributor) & Markus Muttenthaler (Contributor)

5 Dec 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Disulfide bonds – folding, stability and mimetics

Markus Muttenthaler (Invited speaker)

5 Sep 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Multivalent Ligand Design – Chemistry and Applications

Markus Muttenthaler (Speaker)

3 Dec 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Chemical strategies to tune potency, selectivity and stability of neuropeptides

Markus Muttenthaler (Speaker)

28 Nov 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Recombinant synthesis and purification of hTFF2 protein in S. Cerevisiae

Kirtikumar Bhaskarrao Jadhav (Speaker), Gerhard Niederacher (Contributor) & Markus Muttenthaler (Contributor)

26 Aug 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


From venoms to drugs

Markus Muttenthaler (Invited speaker)

25 Jun 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Neuropeptide Research – From Molecular Probes to Therapeutic Leads

Markus Muttenthaler (Invited speaker)

30 Oct 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Multivalent Ligand Design – Chemistry and Applications

Markus Muttenthaler (Speaker)

12 Oct 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Molecular probe development for the Oxytocin/Vasopressin signalling system - from nature’s blueprints to chemical engineering’

Markus Muttenthaler (Invited speaker)

27 Jul 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Department of Biological Chemistry

Währinger Straße 38
1090 Wien

T: +43-1-4277-70515

markus.muttenthaler@univie.ac.at