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Assoz. Prof. Dipl.-Ing. Markus Muttenthaler, PhD

T: +43-1-4277-70515

markus.muttenthaler@univie.ac.at

https://www.neuropeptidelab.com/

Summer term 2024

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

530001 SE Seminar in Chemical Biology for post-graduates

Winter term 2023

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270295 VU Chemical Biology

530001 SE Seminar in Chemical Biology for post-graduates

Summer term 2023

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

530001 SE Seminar in Chemical Biology for post-graduates

Touchard, A., Mendel, H. C., Boulogne, I., Herzig, V., Braga Emidio, N., King, G. F., Triquigneaux, M., Jaquillard, L., Beroud, R., De Waard, M., Delalande, O., Dejean, A., Muttenthaler, M., & Duplais, C. (2020). Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms. ACS Pharmacology and Translational Science, 3(6), 1211–1224. https://doi.org/10.1021/acsptsci.0c00119

Braga Emidio, N., Brierley, S. M., Schroeder, C. I., & Muttenthaler, M. (2020). Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract. ACS Pharmacology and Translational Science, 3(4), 583-597. https://doi.org/10.1021/acsptsci.0c00023

Liu, H., Gruber, C. W., Alewood, P. F., Moller, A., & Muttenthaler, M. (2020). The oxytocin receptor signalling system and breast cancer: a critical review. Oncogene: including Oncogene Reviews, 39, 5917-5932. https://doi.org/10.1038/s41388-020-01415-8

Braga Emidio, N., Baik, H., Lee, D., Stuermer, R., Heuer, J., Elliott, A. G., Blaskovich, M. A. T., Haupenthal, K., Tegtmeyer, N., Hoffmann, W., Schroeder, C. I., & Muttenthaler, M. (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action (vol 75, pg 5602, 2020). Chemical Communications, 56(51), 7049-7049. https://doi.org/10.1039/d0cc90250k

Emidio, N. B., Baik, H., Lee, D., Stuermer, R., Heuer, J., Elliott, A. G., Blaskovich, M. A. T., Haupenthal, K., Tegtmeyer, N., Hoffmann, W., Schroeder, C., & Muttenthaler, M. (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56(47), 6420-6423. https://doi.org/10.1039/d0cc02321c

Heuer, J., Heuer, F., Stuermer, R., Harder, S., Schlueter, H., Emidio, N. B., Muttenthaler, M., Jechorek, D., Meyer, F., & Hoffmann, W. (2020). The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions. International Journal of Molecular Sciences, 21(7), [2508]. https://doi.org/10.3390/ijms21072508

Jadhav, K. B., Woolcock, K. J., & Muttenthaler, M. (2020). Anhydrous hydrogen fluoride cleavage in boc solid phase peptide synthesis. In W. M. Hussein, M. Skwarczynski, & I. Toth (Eds.), Peptide Synthesis: Methods and Protocols (Vol. 2103, pp. 41-57). Humana Press, Springer. Methods in Molecular Biology https://doi.org/10.1007/978-1-0716-0227-0_4

Muttenthaler, M., Nevin, S. T., Inserra, M., Lewis, R. J., Adams, D. J., & Alewood, P. F. (2020). On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe. Australian Journal of Chemistry, 73(4), 327-333. https://doi.org/10.1071/CH19456

Dürrauer, L., Muratspahic, E., Gattringer, J., Keov, P., Mendel, H. C., Pfleger, K. D. G., Muttenthaler, M., & Gruber, C. W. (2019). I8-arachnotocin-an arthropod- derived G protein-biased ligand of the human vasopressin V-2 receptor. Scientific Reports, 9(1), [19295]. https://doi.org/10.1038/s41598-019-55675-w

Jin, A-H., Muttenthaler, M., Dutertre, S., Himaya, S. W. A., Kaas, Q., Craik, D. J., Lewis, R. J., & Alewood, P. F. (2019). Conotoxins: Chemistry and Biology. Chemical Reviews, 119(21), 11510-11549. https://doi.org/10.1021/acs.chemrev.9b00207

Emidio, N. B., Hoffmann, W., Brierley, S. M., & Muttenthaler, M. (2019). Trefoil Factor Family: Unresolved Questions and Clinical Perspectives. Trends in Biochemical Sciences, 44(5), 387-390. https://doi.org/10.1016/j.tibs.2019.01.004

Liutkeviciute, Z., Gil-Mansilla, E., Eder, T., Casillas-Perez, B., Di Giglio, M. G., Muratspahic, E., Grebien, F., Rattei, T., Muttenthaler, M., Cremer, S., & Gruber, C. W. (2018). Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal, 32(12), 6808-6821. https://doi.org/10.1096/fj.201800443

Herzig, V., de Araujo, A. D., Greenwood, K. P., Chin, Y. K. Y., Windley, M. J., Chong, Y., Muttenthaler, M., Mobli, M., Audsley, N., Nicholson, G. M., Alewood, P. F., & King, G. F. (2018). Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides. Biomedicines, 6(3), [90]. https://doi.org/10.3390/biomedicines6030090

Conibear, A. C., & Muttenthaler, M. (2018). Advancing the Frontiers of Chemical Protein Synthesis-The 7th CPS Meeting, Haifa, Israel. Cell Chemical Biology, 25(3), 247-254. https://doi.org/10.1016/j.chembiol.2018.03.001

Arrowsmith, S., Keov, P., Muttenthaler, M., & Gruber, C. W. (2018). Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development. Journal of Visualized Experiments, 2018(131), [e56639]. https://doi.org/10.3791/56639

Muttenthaler, M., Andersson, A., Vetter, I., Menon, R., Busnelli, M., Ragnarsson, L., Bergmayr, C., Arrowsmith, S., Deuis, J. R., Chiu, H. S., Palpant, N. J., O'Brien, M., Smith, T. J., Wray, S., Neumann, I. D., Gruber, C. W., Lewis, R. J., & Alewood, P. F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10(508), [eaan3398]. https://doi.org/10.1126/scisignal.aan3398

Muttenthaler, M. (2017). Multivalent Ligand Design – Chemistry and Applications. In Conference Proceedings

Breger, J. C., Muttenthaler, M., Delehanty, J. B., Thompson, D. A., Oh, E., Susumu, K., Deschamps, J. R., Anderson, G. P., Field, L. D., Walper, S. A., Dawson, P. E., & Medintz, I. L. (2017). Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery. Nanoscale, 9(29), 10447-10464. https://doi.org/10.1039/c7nr03362a

Di Giglio, M. G., Muttenthaler, M., Harpsøe, K., Liutkeviciute, Z., Keov, P., Eder, T., Rattei, T., Arrowsmith, S., Wray, S., Marek, A., Elbert, T., Alewood, P. F., Gloriam, D. E., & Gruber, C. W. (2017). Development of a human vasopressin V_1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports, 7, [41002]. https://doi.org/10.1038/srep41002

Wan, J., Mobli, M., Brust, A., Muttenthaler, M., Andersson, Å., Ragnarsson, L., Castro, J., Vetter, I., Huang, J. X., Nilsson, M., Brierley, S. M., Cooper, M. A., Lewis, R. J., & Alewood, P. F. (2017). Synthesis of Multivalent [Lys⁸]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses. Australian Journal of Chemistry, 70(2), 162-171. https://doi.org/10.1071/CH16407

Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker), Michaela Lang (Contributor), Athanasios Makristathis (Contributor), Christoph Gasche (Contributor) & Markus Muttenthaler (Contributor)

24 Nov 2023