Nanomedicine utilizes nanotechnology to provide better treatments and improve the quality of patients’ lives. Among the in-progress materials, mesoporous silica nanoparticles (MSNs) have shown great promise and potential to be brought from bench to bedside. This talk encompasses designing functionalized MSNs for diagnosis and theranostic, and studying MSNs behaviors in protein containing environments in attempt to narrow the knowledge gap between in vitro and in vivo scenarios.
Firstly, fluoridated MSNs were demonstrated as potential ultrasound therapeutic agents. Meanwhile, the influences of textural and surface properties of MSNs on the responsiveness were investigated. 1,2 Then, FePt NPs functionalized MSNs were fabricated for MRI and NIR photothermal therapy, and significant synergistic effect was observed combining anticancer drug topotecan and NIR irradiation. 3 Subsequently, Pt oxides (PtO x ) functionalized MSNs were used to study Pt release kinetics and changes in chemical state for better understanding of the release of bioactive Pt species reported
previously. Lastly, protein adsorption on a serial of MSNs in both in vitro and in vivo relevant conditions were investigated. Strong protein concentration dependent corona patterns were revealed, whereas the surface chemical group and MSNs textural property played minor roles. In addition, at clinically practical MSNs concentrations, protein concentration could significantly impact the journey of MSNs morphological evolution over the dissolution time course.
References:
[1] Q. F. Jin and C. Y. Lin et al. Ultrason. Sonochem. 2017, 36, 262–269.
[2] Q. F. Jin and C. Y. Lin et al. Langmuir 2018, 34, 1256−1265.
[3] C. Y. Lin et al. J. Mater. Chem. B 2017, 5, 7598-7607.
Chih-Yu Lin received her Ph.D. in Department of Chemistry, National Tsing-Hua
University, Taiwan in 2019 under the supervision of Prof. Chia-Min Yang. During Aug. 2017- Aug.
2018, she was under a DAAD-MOST scholarship program and working with Prof. Mika Lindén in
Inorganic Institute II, Ulm University, Germany. She is currently a postdoctoral researcher in
Department of Chemistry, National Tsing-Hua University, Taiwan and working in Ulm University
under a scientific travel grant. Her researches focus on fabrication of mesoporous silica particles
(MSNs)-based composites for biomedical applications and MSNs behaviors in the presence of serum
proteins.