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[Zurück]

Assoz. Prof. Mag. Dr. Christian Kowol

T: +43-1-4277-52611

christian.kowol@univie.ac.at

http://anorg-chemie.univie.ac.at/research/bioinorganic-chemistry/group-christian-kowol/

Sommersemester 2024

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270186 PR Praktikum Koordinationschemie

270304 PR Praktikum Bioanorganische Chemie

Wintersemester 2023

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270029 PR Chemisches Grundpraktikum I - präparative Laborübungen

270186 PR Praktikum Koordinationschemie

270304 PR Praktikum Bioanorganische Chemie

270314 VO Bioanorganische Chemie

Sommersemester 2023

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270186 PR Praktikum Koordinationschemie

270304 PR Praktikum Bioanorganische Chemie

Pósa, V., Federa, A., Cseh, K., Wenisch, D., Spengler, G., May, N. V., Lihi, N., Samu, G. F., Jakupec, M. A., Keppler, B. K., Kowol, C. R., & Enyedy, É. A. (2024). A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions. Inorganic Chemistry, 63(5), 2401-2417. https://doi.org/10.1021/acs.inorgchem.3c03259

Teixeira, R. G., Stefanelli, A., Pilon, A., Warmers, R., Fontrodona, X., Romero, I., Costa, P. J., Villa de Brito, M. J., Hudec, X., Pirker, C., Türck, S., Antunes, A. M. M., Kowol, C. R., Ott, I., Brozovic, A., Sombke, A., Eckhard, M., Tomaz, A. I., Heffeter, P., & Valente, A. (2024). Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.3c01036

Kastner, A., Mendrina, T., Babu, T., Karmakar, S., Poetsch, I., Berger, W., Keppler, B. K., Gibson, D., Heffeter, P., & Kowol, C. R. (2023). Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs. Inorganic Chemistry Frontiers, 11(2), 534-548. https://doi.org/10.1039/d3qi02032k

Kastner, A., Schueffl, H., Yassemipour, P. A., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes. Angewandte Chemie - International Edition, 62(46), [e202311468]. https://doi.org/10.1002/anie.202311468

Liu, X., Wenisch, D., Dahlke, P., Jordan, P. M., Jakupec, M. A., Kowol, C. R., Liebing, P., Werz, O., Keppler, B. K., & Weigand, W. (2023). Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs. European Journal of Medicinal Chemistry, 257, [115515]. https://doi.org/10.1016/j.ejmech.2023.115515

Schaier, M., Falcone, E., Prstek, T., Vileno, B., Hager, S., Keppler, B. K., Heffeter, P., Koellensperger, G., Faller, P., & Kowol, C. R. (2023). Human serum albumin as a copper source for anticancer thiosemicarbazones. Metallomics, 15(8), [mfad046]. https://doi.org/10.1093/mtomcs/mfad046

Caban, M., Koblmueller, B., Groza, D., Schueffl, H. H., Terenzi, A., Tolios, A., Mohr, T., Mathuber, M., Kryeziu, K., Jaunecker, C., Pirker, C., Keppler, B. K., Berger, W., Kowol, C. R., & Heffeter, P. (2023). A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo. Cancer Letters, 565, [216237]. https://doi.org/10.1016/j.canlet.2023.216237

Kastner, A., Mendrina, T., Bachmann, F., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs. Inorganic Chemistry Frontiers, 10(14), 4126-4138. https://doi.org/10.1039/d3qi00968h

Strasser, P., Montsch, B., Weiss, S., Sami, H., Kugler, C., Hager, S., Schueffl, H., Mader, R., Brüggemann, O., Kowol, C. R., Ogris, M., Heffeter, P., & Teasdale, I. (2023). Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo. Small, 19(22), [2300767]. https://doi.org/10.1002/smll.202300767

Mendrina, T., Poetsch, I., Schueffl, H., Baier, D., Pirker, C., Ries, A., Keppler, B. K., Kowol, C. R., Gibson, D., Grusch, M., Berger, W., & Heffeter, P. (2023). Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands. Pharmaceutics, 15(2), [677]. https://doi.org/10.3390/pharmaceutics15020677

Solta, A., Boettiger, K., Kovacs, I., Lang, C., Megyesfalvi, Z., Ferk, F., Misík, M., Hoetzenecker, K., Aigner, C., Kowol, C. R., Knasmueller, S., Grusch, M., Szeitz, B., Rezeli, M., Dome, B., & Schelch, K. (2023). Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair. Clinical Cancer Research, 29(22), 4644-4659. https://doi.org/10.1158/1078-0432.CCR-23-1795

Liu, X., Barth, M-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Keppler, B. K., Gibson, D., & Weigand, W. (2022). Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity. Chemistry & Biodiversity, 19(10), [e202200695]. https://doi.org/10.1002/cbdv.202200695

Schwendenwein, A., Boettiger, K., Kovacs, I., Barany, N., Megyesfalvi, Z., Grusch, M., Kowol, C., Rezeli, M., Hoetzenecker, K., Dome, B., & Schelch, K. (2022). EP14.02-00 Cisplatin in Combination with Entinostat exerts Synergistic Antineoplastic Activity in Small Cell Lung Cancer. Journal of thoracic oncology, 17(9), S537-S537.

Posa, V., Stefanelli, A., Nunes, J. H. B., Hager, S., Mathuber, M., May, N., Berger, W., Keppler, B. K., Kowol, C. R., Enyedy, E. A., & Heffeter, P. (2022). Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance. Cancers, 14(18), [4455]. https://doi.org/10.3390/cancers14184455

Falcone, E., Ritacca, A. G., Hager, S., Schueffl, H., Vileno, B., El Khoury, Y., Hellwig, P., Kowol, C. R., Heffeter, P., Sicilia, E., & Faller, P. (2022). Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH. Journal of the American Chemical Society, 144(32), 14758-14768. https://doi.org/10.1021/jacs.2c05355

Posa, V., Hajdu, B., Toth, G., Domotor, O., Kowol, C. R., Keppler, B. K., Spengler, G., Gyurcsik, B., & Enyedy, E. A. (2022). The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity. Journal of Inorganic Biochemistry, 231, [111786]. https://doi.org/10.1016/j.jinorgbio.2022.111786

Fronik, P., Gutmann, M., Vician, P., Stojanovic, M., Kastner, A., Heffeter, P., Pirker, C., Keppler, B. K., Berger, W., & Kowol, C. R. (2022). A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance. Communications Chemistry, 5(1), [46]. https://doi.org/10.1038/s42004-022-00661-z

Liu, X., Wenisch, D., Barth, M-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Gibson, D., Keppler, B. K., & Weigand, W. (2022). Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions, 51(44), 16824-16835. https://doi.org/10.1039/d2dt02217f

Kandioller, W., Theiner, J., Keppler, B. K., & Kowol, C. R. (2021). Elemental analysis: an important purity control but prone to manipulations. Inorganic Chemistry Frontiers, 9(3), 412-416. https://doi.org/10.1039/d1qi01379c

Terenzi, A., La Franca, M., van Schoonhoven, S., Panchuk, R., Martinez, A., Heffeter, P., Gober, R., Pirker, C., Vician, P., Kowol, C. R., Stoika, R., Salassa, L., Rohr, J., & Berger, W. (2021). Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism. Communications Chemistry, 4(1), [162]. https://doi.org/10.1038/s42004-021-00600-4