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Assoz. Prof. Dr. Samuel Meier-Menches

T: +43-1-4277-52373

samuel.meier-menches@univie.ac.at

meiermencheslab.univie.ac.at

In an interdisciplinary environment that combines analytical chemistry, synthetic chemistry, biology and medicine, we are interested in discovering modes of action of approved drugs, drug candidates and investigational drugs for the treatment of chronic diseases. The mode of action explains the connection of the molecular interaction of the therapeutic molecule with a target and the subsequent sequence of events that impact on physiology. We use mass spectrometry-based proteomics, chemoproteomics and metabolomics to uncover detailed modes of action in preclinical in vitro and in vivo models, as well as in patients.

Sommersemester 2026

270013 SE Erstellen der Bachelorarbeit B - Analytische Chemie + Lebensmittelchemie

270084 LP Grundpraktikum Analytische Chemie

270103 PR Wahlfachpraktikum B (Bachelormodul) - Analytische Chemie + Lebensmittelchemie

270130 PR Spektroskopisches Praktikum - UV/VIS,IR/RAMAN,NMR

270189 PR Metabolic Phenotyping

270297 VO Rezeptor Liganden Wechselwirkungen

530017 SE Bioanalysis and Translational Research

950274 VO VO Allgemeine und angewandte Biochemie

Wintersemester 2025

270013 SE Erstellen der Bachelorarbeit B - Analytische Chemie + Lebensmittelchemie

270084 LP Grundpraktikum Analytische Chemie

270103 PR Wahlfachpraktikum B (Bachelormodul) - Analytische Chemie + Lebensmittelchemie

270130 PR Spektroskopisches Praktikum - UV/VIS,IR/RAMAN,NMR

270244 PR Massenspektrometrie I

270251 VU Auswertestrategien großer Datensätze

Wasinger, D., Stolz, K., Wolf, M., Gmeiner, G., Bileck, A., Hagn, G., Meier-Menches, S. M., Kanz, F., & Gerner, C. (2026). Analysis of postmortem dermal extracts is an efficient illicit drug screening method supporting forensic medicine. Scientific Reports, 16(1), Artikel 14183. https://doi.org/10.1038/s41598-026-45056-5

Fiduccia, I., Vitale, E., Varrica, R., Ricci, D., Marino, S., Zito, A., Pace, A., Colige, A., Moutschen, M., Borutzki, Y., Bileck, A., Meier-Menches, S. M., Lentini, L., & Pibiri, I. (2026). Beyond the stop: Oxadiazole TRIDs restore LRBA protein expression in nonsense-driven primary immunodeficiency. Molecular Therapy Nucleic Acids, 37(1), Artikel 102808. https://doi.org/10.1016/j.omtn.2025.102808

Bormio Nunes, J. H., Hacker, C., Caban, M., Valcanover, D., Yassemipour, P. A., Türck, S., Ott, I., Skos, L., Bileck, A., Gerner, C., Meier-Menches, S. M., Mohr, T., Berger, W., Kowol, C. R., & Heffeter, P. (2026). Structure-Activity Relationships of Silver(I)- and Gold(I)-NHC Complexes Reveal Distinctly Different Responses of Cisplatin-Resistant Ovarian Cancer to Bis-NHC-Gold(I) Derivatives. Journal of Medicinal Chemistry, 69(3), 2462-2480. Artikel PMID 9716531. https://doi.org/10.1021/acs.jmedchem.5c02355

Thomas, S. R., Iellici, T., Park, M., Klaus, E., Bileck, A., Gerner, C., Meier-Menches, S. M., & Casini, A. (2026). A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System. ACS Chemical Biology, 21(1), 170-186. https://doi.org/10.1021/acschembio.5c00860

Küssner, K., Wolf, M., Cucchiaro, A., Hartinger, C. G., Meier-Menches, S., & Cziferszky, M. (2026). Competitive LC-MS/MS assay to investigate protein metalation dynamics. Inorganic Chemistry Frontiers. Vorzeitige Online-Publikation. https://doi.org/10.1039/d5qi02457a

Moliterno, P., Meier-Menches, S., & Widhalm, K. (2026). Eccrine Sweat Collection: An Innovative Approach to Understanding and Preventing Childhood Obesity. Pädiatrie & Pädologie. Vorzeitige Online-Publikation. https://doi.org/10.1007/s00608-026-01371-8

Rogozarski, J., Steiner-Gager, GM., Preindl, K., Wicik, Z., Eyileten, C., Skos, C., Gerner, C., Dizdarevic, A., Postula, M., Meier-Menches, SM., & Siller-Matula, JM. (2026). Plasma metabolomic profiling of patients with acute coronary syndrome treated with potent platelet inhibitors. European heart journal : Supplements, 28(Suppl. 3 SI), Artikel suag056168. https://doi.org/10.1093/eurheartjsupp/suag056.168

Rocha, M., Petsch, J., Schultheis, D., Zrelski, M. M., Fichtinger, P., Koneczny, I., Meier-Menches, S., Wiche, G., Schröder, R., & Winter, L. (2025). Consequences of plectin ablation on the various intermediate filament systems in skeletal muscle. European Journal of Cell Biology, 104(4), Artikel 151522. https://doi.org/10.1016/j.ejcb.2025.151522

Karasová, M., Jobst, M., Framke, D., Bergen, J., Meier-Menches, S., Keppler, B., Koellensperger, G., Zanghellini, J., Gerner, C., & Del Favero, G. (2025). Mechanical cues rewire lipid metabolism and support chemoresistance in epithelial ovarian cancer cell lines OVCAR3 and SKOV3. Cell communication and signaling, 23(1), Artikel 193. https://doi.org/10.1186/s12964-025-02144-9

Outla, Z., Kosla, J., Prechova, M., Frick, L., Janker-Bortel, P., Borutzki, Y., Bileck, A., Gerner, C., Meier-Menches, S. M., Osmanagic-Myers, S., & Gregor, M. (2025). Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin. Molecular Oncology. Vorzeitige Online-Publikation. https://doi.org/10.1002/1878-0261.70186

Wolf, M., Wasinger, D., Donhauser, V., Moliterno, P., Keppler, B. K., Gerner, C., Widhalm, K., & Meier-Menches, S. M. (2025). Eccrine sweat reveals normalization of artificial sweetener levels in children with overweight after nutritional education. iScience, 28(11), Artikel 113736. https://doi.org/10.1016/j.isci.2025.113736

Jobst, M., Crudo, F., Marko, D., Bileck, A., Meier-Menches, S. M., Gerner, C., & Del Favero, G. (2025). Retrograde rearrangement of mitochondria correlates with nuclear deformation and genotoxic damage. iScience, 28(8), Artikel 112955. https://doi.org/10.1016/j.isci.2025.112955

Rosner, A., Skos, L., Mendrina, T., Baier-Romfeld, D., Hejl, M., Borutzki, Y., Gradl, M., Geisler, H., Mohr, T., Legin, A., Jakupec, M. A., Bileck, A., Gerner, C., Koellensperger, G., Heffeter, P., Berger, W., Keppler, B. K., Kandioller, W., & Meier-Menches, S. M. (2025). Selectivity for TP53 signalling drives the mode of action of a highly potent N,O,O-tridentate naphthoquinone-based organo-ruthenium anticancer drug candidate. Chemical Science. Vorzeitige Online-Publikation. https://doi.org/10.1039/d5sc00735f

Schmidl, D., Pai, V., Bileck, A., Hommer, N., Janku, P., Lindner, T., Kauer, V., Rumpf, B., Haslacher, H., Hagn, G., Meier-Menches, S. M., Schmetterer, L., Gerner, C., & Garhöfer, G. (2025). Retinal microcirculation in patients that have recovered from acute COVID-19 infection. Journal of Vascular Research, 62(SUPPL 1), Artikel Meeting Abstract 90.

Outla, Z., Oyman-Eyrilmez, G., Korelova, K., Prechova, M., Frick, L., Sarnova, L., Bisht, P., Novotna, P., Kosla, J., Janker-Bortel, P., Borutzki, Y., Bileck, A., Gerner, C., Rahbari, M., Rahbari, N., Birgin, E., Kvasnicova, B., Galisova, A., Sulkova, K., ... Gregor, M. (2025). Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis. eLife, 13. https://doi.org/10.7554/eLife.102205

Bolliger, M., Wasinger, D., Brunmair, J., Hagn, G., Wolf, M., Preindl, K., Reiter, B., Bileck, A., Gerner, C., Fitzal, F., & Meier-Menches, S. M. (2025). Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria. The EPMA journal, 16(1), 165-182. https://doi.org/10.1007/s13167-025-00396-6

Zott, T., Wolf, M., Plessl-Walder, G., Regele, H., Bergmann, M., Meier-Menches, S. M., Gerner, C., Silberhumer, G. R., & Bileck, A. (2025). Proteomic Analysis of FFPE Tissue Samples Identifies Potential Molecular Mechanisms Mediating Resistance to Radiotherapy in Rectal Cancer. Journal of Proteome Research. Vorzeitige Online-Publikation. https://doi.org/10.1021/acs.jproteome.5c00114

Hagn, G., Meier-Menches, S. M., Plessl-Walder, G., Mitra, G., Mohr, T., Preindl, K., Schlatter, A., Schmidl, D., Gerner, C., Garhöfer, G., & Bileck, A. (2024). Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets. Journal of Proteome Research, 23(8), 3064-3075. https://doi.org/10.1021/acs.jproteome.3c00761

Gerner, I., Meier-Menches, S. M., Bileck, A., Gueltekin, S., Gerner, C., & Jenner, F. (2024). Metabolic Profiling Of Tendon And Cartilage Healing. Tissue engineering. Part A, 30(15-16), S6-S7.

Skos, L., Schmidt, C., Thomas, S. R., Park, M., Geiger, V., Wenisch, D., Bonsignore, R., Del Favero, G., Mohr, T., Bileck, A., Gerner, C., Casini, A., & Meier-Menches, S. M. (2024). Gold-templated covalent targeting of the CysSec-dyad of thioredoxin reductase 1 in cancer cells. Cell Reports Physical Science, 5(7), Artikel 102072. https://doi.org/10.1016/j.xcrp.2024.102072