Ass.-Prof. Dr. Samuel Matthias Meier-Menches, Privatdoz.
Institut für Analytische Chemie, Institut für Anorganische Chemie & Joint Metabolome Facility, Fakultät für Chemie, Universität Wien
Small molecule effects in complex systems
Small molecules are widely used to modulate (patho-)physiological processes in multicellular systems. Yet, identifying interactors of small molecules and experimentally connecting their impact to molecular pathways remains challenging. Affinity-based proteomics in combination with response profiling will be highlighted as a viable approach to reveal potential binding partners of drug candidates in cells. This will be discussed in conjunction with validation strategies that are necessary to distinguish bystander from effector molecules. Finally, novel model systems are currently developed to account for the multi-factorial nature of chronic diseases and to effectively normalize disease processes.
Ass.-Prof. Dr. Thomas Mindt, Privatdoz.
Bioinorganic Radiochemistry, Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna
Radioactive labeled molecules for diagnosis and therapy of diseases
Radioactive labeled molecules (radiopharmaceuticals, radiotracer) are used in nuclear medicine for the non-invasive diagnosis (imaging) and therapy of diseases. Different metallic and non-metallic radioactive isotopes of elements are available for radiotracer development. Gamma- (g) and positron- (b+) emitter are used for imaging by Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) respectively, whereas particle emitters (a, b-) are employed for internal radiation therapy. Radiometals offer the unique possibility to exchange a diagnostic by a therapeutic isotope, therefore enabling theranostic approaches. Examples of the development of radiometal-based radiopharmaceuticals specific for a molecular target important in oncology will be presented.
HOW TO PARTICIPATE:
Pls. join us either in Loschmidt Hörsaal (HS2), Faculty of Chemistry, Währinger Straße 42, 1090 Vienna
- RESERVE A SEAT for Monday, 11th, 4pm! (CLOSED)
Please note that a seat reservation is mandatory for on site participation!
Or join us ONLINE:
To participate in on-site courses, all participants and teachers/employees, on request, have to provide valid proof of being tested or vaccinated or of having recovered from a COVID-19 infection. There will be comprehensive checks. Only labelled seats may be used in course rooms. All participants must wear an FFP2 face mask (except for persons lecturing, oral contributions).
