Univ.-Prof. Dr. Thomas Böttcher
Thomas Böttcher
1 - 20 out of 47



Rasoulimehrabani, H., Riva, A., Inan, D., Hodžić, A., Hausmann, B., Nikolov, G., Khadem, S., Hieger, N., Wiesenbauer, J., Kaiser, C., Filz, V., Böttcher, T., & Berry, D. (2025). Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting. Gut microbes, 17(1), Article 2525482. https://doi.org/10.1080/19490976.2025.2525482


Mix, A. K., Nguyen, T. H. N., Schuhmacher, T., Szamosvári, D., Muenzner, P., Haas, P., Heeb, L., Wami, H. T., Dobrindt, U., Delikkafa, Y. Ö., Mayer, T. U., Böttcher, T., & Hauck, C. R. (2025). A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system. Nature Microbiology, 10(4), 939-957. Article 35. https://doi.org/10.1038/s41564-025-01968-y

Burger, I., Schmal, M., Peikert, K., Fourtis, L., Suster, C., Stanetty, C., Schnalzer, D., Hufnagel, B., Böttcher, T., Birner-Gruenberger, R., Mach, R. L., Mach-Aigner, A. R., Schittmayer, M., & Zimmermann, C. (2025). Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. Biotechnology for biofuels and bioproducts, 18(1), 1-16. Article 32. https://doi.org/10.1186/s13068-025-02628-3

Pereira, F. C., Ge, X., Kristensen, J. M., Kirkegaard, R. H., Maritsch, K., Szamosvári, D., Imminger, S., Seki, D., Shazzad, J. B., Zhu, Y., Decorte, M., Hausmann, B., Berry, D., Wasmund, K., Schintlmeister, A., Böttcher, T., Cheng, J.-X., & Wagner, M. (2024). The Parkinson's disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration. Nature Microbiology, 9(12), 3165–3183. https://doi.org/10.1038/s41564-024-01853-0

Steuer, J., Sinn, M., Eble, F., Rütschlin, S., Böttcher, T., Hartig, J. S., & Peter, C. (2024). Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch. NAR Genomics and Bioinformatics, 6(3), 1-12. Article lqae132. https://doi.org/10.1093/nargab/lqae132

Savchenko, V., Jaegers, M., Rasche, R., Herrmann, E., König, S., Kümmel, D., Böttcher, T., Fetzner, S., & Ernst, S. (2024). Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis. Cell Reports Physical Science, 5(8), 1-20. Article 102100. https://doi.org/10.1016/j.xcrp.2024.102100



Ückert, A. K., Rütschlin, S., Gutbier, S., Wörz, N. C., Miah, M. R., Martins, A. C., Hauer, I., Holzer, A. K., Meyburg, B., Mix, A. K., Hauck, C., Aschner, M., Böttcher, T., & Leist, M. (2023). Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration. Environment International, 180, 1-16. Article 108229. https://doi.org/10.1016/j.envint.2023.108229


Schmid, P., Peñalver, L., & Böttcher, T. (2022). A ligand selection strategy to customize small molecule probes for activity-based protein profiling (LS-ABPP). In E. E. Carlson (Ed.), Chemical Microbiology Part A (pp. 23-58). Elsevier. https://doi.org/10.1016/bs.mie.2022.01.008

Klein, K., Garkov, D., Rütschlin , S., Böttcher, T., & Schreiber, F. (2021). QSDB—a graphical Quorum Sensing Database. Database: The Journal of Biological Databases and Curation, 2021, Article baab058. https://doi.org/10.1093/database/baab058

Klein, K., Garkov, D., Ruetschlin, S., Boettcher, T., & Schreiber, F. (2021). QSDB-a graphical Quorum Sensing Database (vol 2021, baab058, 2021). Database: The Journal of Biological Databases and Curation, 2021, Article baab071. https://doi.org/10.1093/database/baab071



Prothiwa, M., Filz, V., Oehler, S., & Boettcher, T. (2021). Inhibiting quinolone biosynthesis of Burkholderia. Chemical Science, 12(20), 6908-6912. https://doi.org/10.1039/d0sc06167k

1 - 20 out of 47

Microbiome-induced pruritus in atopic dermatitis patients

Wittlinger, J.-P. (Speaker), Grey, L. (Contributor), Fischer, M. (Contributor), Stary, G. (Contributor), Böttcher, T. (Contributor) & Berry, D. (Contributor)

16 Sept 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Targeting Neisseria gonorrhoea via its toxin-antitoxin system

Böttcher, T. (Invited speaker)

20 May 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Phage blocker: Discovery of a novel bacteriophage antiviral for phageome modulation

Plöchl, K. (Speaker) & Böttcher, T. (Contributor)

19 Feb 2025

Activity: Talks and presentationsTalk or oral contributionScience to Science


Expecting the Unexpected in the Chemistry of Microbial Interactions

Böttcher, T. (Invited speaker)

3 Oct 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Identification and Investigation of Aerugine as Trigger of Dopaminergic Neurodegeneration

Wörz, N. C. (Speaker), Ückert, A. K. (Contributor), Rütschlin , S. (Contributor), Miah, M. R. (Contributor), Martins, A. C. (Contributor), Hauer, I. (Contributor), Holzer, A. K. (Contributor), Meyburg, B. (Contributor), Mix, A.-K. (Contributor), Anderl, F. (Contributor), Hauck, C. R. (Contributor), Aschner, M. (Contributor), Leist, M. (Contributor) & Böttcher, T. (Contributor)

12 Sept 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploiting, and Manipulating the Secondary Metabolite Repertoire of Human Pathogens

Böttcher, T. (Invited speaker)

21 Aug 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploring and Exploiting the Biochemistry of Microbial Interactions

Böttcher, T. (Invited speaker)

3 May 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Microbial Metabolites Mediating Interactions in the Environment

Böttcher, T. (Invited speaker)

26 Apr 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


A Modular ABPP Approach to Target Protease AgrB in the Pathogen S. aureus

Jost, E. (Speaker) & Böttcher, T. (Contributor)

13 Mar 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Identification and investigation of aerugine as trigger of dopaminergic neurodegeneration

Wörz, N. C. (Speaker), Ückert, A. K. (Contributor), Rütschlin , S. (Contributor), Gutbier, S. (Contributor), Miah, M. R. (Contributor), Martins, A. C. (Contributor), Hauer, I. (Contributor), Holzer, A. K. (Contributor), Meyburg, B. (Contributor), Mix, A.-K. (Contributor), Anderl, F. (Contributor), Hauck, C. R. (Contributor), Aschner, M. (Contributor), Leist, M. (Contributor) & Böttcher, T. (Contributor)

13 Mar 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


Chemical Biology of Virus-Microbe-Host Interactions

Böttcher, T. (Invited speaker)

14 Feb 2024

Activity: Talks and presentationsTalk or oral contributionScience to Science


A Chemist’s Approach Towards Microbe-Host Interactions

Böttcher, T. (Invited speaker)

9 Nov 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploiting Microbial Metabolites as Narrow- Spectrum Antibiotics

Böttcher, T. (Speaker)

11 Oct 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Small molecules in a microbial theatre

Böttcher, T. (Invited speaker)

6 Jun 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploring and Exploiting the Chemistry of Microbial Interactions

Böttcher, T. (Invited speaker)

31 May 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Biosynthetic Flexibility of Pseudomonas aeruginosa Leads to Hydroxylated 2-Alkylquinolones with Proinflammatory Host Response

Savchenko, V. (Speaker), Szamosvari, D. (Contributor), Bao, Y. (Contributor), Pignitter, M. (Contributor) & Böttcher, T. (Contributor)

22 Mar 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Chemical tools for modulating protein degradation

Böttcher, T. (Invited speaker)

12 Feb 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Exploring and Exploiting the Chemistry of Microbial Interactions

Böttcher, T. (Invited speaker)

26 Jan 2023

Activity: Talks and presentationsTalk or oral contributionScience to Science


Small Molecules Controlling Microbial Interactions

Böttcher, T. (Invited speaker)

3 Nov 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


Small Molecules Controlling Microbial Interactions

Böttcher, T. (Invited speaker)

29 Sept 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


The Chemistry of Microbial Interactions

Böttcher, T. (Invited speaker)

13 Jun 2022

Activity: Talks and presentationsTalk or oral contributionScience to Science


From Molecules to Life – a Question of Molecular Complexity

Böttcher, T. (Invited speaker)

5 Oct 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Activity-Based Probes as Chemical Tools for Targeting Proteases

Böttcher, T. (Invited speaker)

13 Jul 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Microbial metabolites for metal scavenging, defense, and signaling

Böttcher, T. (Invited speaker)

24 Jun 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Small molecules controlling prophage induction

Jancheva, M. (Speaker) & Böttcher, T. (Contributor)

18 Mar 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


A chemical tool kit for the discovery of customized enzyme inhibitors

Böttcher, T. (Invited speaker)

8 Mar 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


Chemical tools for targeting the proteases of SARS-CoV-2

Böttcher, T. (Invited speaker)

28 Jan 2021

Activity: Talks and presentationsTalk or oral contributionScience to Science


A Device for Phage Capture and Release (PhageTRAP)

Böttcher, T. (Project Lead)

1/04/2630/09/27

Project: Research funding


Chemical tools for targeting bacterial effector proteins

Böttcher, T. (Project Lead)

1/04/2631/03/30

Project: Research funding


Anti-Infectives Drug Discovery

Rollinger, J. M. (Project Lead), Dailey, L. A. (Co-Lead), Orts, J. (Co-Lead), Böttcher, T. (Co-Lead), Schmidt, M. (Co-Lead), Rademacher, C. J. H. (Co-Lead), Schützenmeister, N. (Co-Lead), Zotchev, S. (Co-Lead), Kirchmair, J. (Co-Lead) & Ortmayr, K. (Co-Lead)

1/07/2531/01/30

Project: Research funding


Microbiom-induced pruritus

Berry, D. (Project Lead) & Böttcher, T. (Co-Lead)

15/02/2314/02/27

Project: Research funding



Department of Biological Chemistry

Deputy Head

Währinger Straße 38
1090 Wien

T: +43-1-4277-70550

thomas.boettcher@univie.ac.at