Details

emer. o. Univ.-Prof. Dr. Dr. Bernhard Keppler

T: +43-1-4277-52602

bernhard.keppler@univie.ac.at

Summer term 2025

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

530033 SE Institute Seminar Master and PhD Inorganic Chemistry

Summer term 2024

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270165 VO Chemistry of Actinides

270186 PR Practical Course Coordination Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

270318 EX Excursions to the chemical-producing large-scale industry

530029 SE Strategies für the development of tumor inhibiting metal complexes - for Master- and PhD-Students of the department

Pivarcsik, T., Kovács, F., Spengler, G., Nové, M., Keppler, B. K., Kandioller, W., Frank, É., & Enyedy, É. A. (2025). Anticancer organometallic half-sandwich complexes of estrone-derived (N,N) donor ligands with enhanced aqueous solubility. Journal of Inorganic Biochemistry, 267, Article 112858. https://doi.org/10.1016/j.jinorgbio.2025.112858

Dijkstra, M., Schueffl, H., Adamova, B., Baumfried, O., Kastner, A., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2025). Exploring the Structure-Activity Relationships of Albumin-Targeted Picoplatin-Based Platinum(IV) Prodrugs. Inorganic Chemistry, 64(5), 2554-2566. https://doi.org/10.1021/acs.inorgchem.4c05269

Caban, M., Fronik, P., Terenzi, A., Federa, A., Bormio Nunes, J. H., Pitek, R., Kirchhofer, D., Schueffl, H. H., Berger, W., Keppler, B. K., Kowol, C. R., & Heffeter, P. (2025). A new fluorescent oxaliplatin(iv) complex with EGFR-inhibiting properties for the treatment of drug-resistant cancer cells. Inorganic Chemistry Frontiers, 12(4), 1538-1552. https://doi.org/10.1039/d4qi03025g

Dijkstra, M., Schueffl, H., Federa, A., Kast, C., Unterlercher, A., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2025). Novel Maleimide Linkers Based on a Piperazine Motif for Strongly Increased Aqueous Solubility. ACS Omega. Advance online publication. https://doi.org/10.1021/acsomega.4c10825

Maier, T., Keppler, B. K., Galanski, M. S., & Varbanov, H. P. (2024). Synthesis and Characterization of (OC-6-33)-Dichloridobis((4-(¹³C₂)ethoxy)-4-(¹³C₄)oxobutanoato)bis((¹⁵N)ethylamine)platinum(IV). Time-Dependent NMR Spectroscopy and HPLC-MS Investigations on its Stability in Cell Culture Medium. European Journal of Inorganic Chemistry, 27(30), Article e202400348. https://doi.org/10.1002/ejic.202400348

Eisen, C., Keppler, B. K., Chin, J. M., Su, X., & Reithofer, M. R. (2024). Fabrication of azido-PEG-NHC stabilized gold nanoparticles as a functionalizable platform. Chemical Science, 15(44), 18524-18533. https://doi.org/10.1039/d4sc04112g

Ivanova, J., Kukeva, R., Stoyanova, R., Zhivkova, T., Abudalleh, A., Dyakova, L., Alexandrova, R., Pashkunova-Martic, I., Theiner, J., Dorkov, P., Hejl, M., Jakupec, M. A., Keppler, B., & Grabchev, I. (2024). New Iron(III)-Containing Composite of Salinomycinic Acid with Antitumor Activity—Synthesis and Characterization. Inorganics, 12(8), Article 206. https://doi.org/10.3390/inorganics12080206

Wróblewska, A. M., Łukawska, E., Wakuła, Z., Zajda, J., Keppler, B. K., Timerbaev, A. R., & Matczuk, M. (2024). Toward the boosted loading of cisplatin drug into liposome nanocarriers. European Journal of Pharmaceutics and Biopharmaceutics, 198, Article 114245. https://doi.org/10.1016/j.ejpb.2024.114245

Matczuk, M., Timerbaev, A. R., Keppler, B. K., & Ruzik, L. (2024). Ionic liquid-mediated drug delivery: A review on progress and challenges focused on poly(ionic liquid) nanoplatforms. Journal of Molecular Liquids, 399, Article 124403. https://doi.org/10.1016/j.molliq.2024.124403

Getreuer, P., Marretta, L., Toyoglu, E., Dömötör, O., Hejl, M., Prado-Roller, A., Cseh, K., Legin, A. A., Jakupec, M. A., Barone, G., Terenzi, A., Keppler, B. K., & Kandioller, W. (2024). Investigating the anticancer potential of 4-phenylthiazole derived Ru(ii) and Os(ii) metalacycles. Dalton Transactions, 53(12), 5567-5579. https://doi.org/10.1039/d4dt00245h

Pósa, V., Federa, A., Cseh, K., Wenisch, D., Spengler, G., May, N. V., Lihi, N., Samu, G. F., Jakupec, M. A., Keppler, B. K., Kowol, C. R., & Enyedy, É. A. (2024). A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions. Inorganic Chemistry, 63(5), 2401-2417. https://doi.org/10.1021/acs.inorgchem.3c03259

Gradwohl, A., Windisch, J., Rosner, A., Heninger, J., Fuhrmann, P. L., Wallner, G., Keppler, B. K., Kandioller, W., & Jirsa, F. (2024). Di-[trioctyl-(8-phenyloctyl)-phosphonium] pamoate: synthesis and characterization of a novel, highly hydrophobic ionic liquid for the extraction of scandium, thorium and uranium. Frontiers in Chemistry, 12, Article 1502232. https://doi.org/10.3389/fchem.2024.1502232

Happl, B., Balber, T., Heffeter, P., Denk, C., Welch, J. M., Köster, U., Alliot, C., Bonraisin, A. C., Brandt, M., Haddad, F., Sterba, J. H., Kandioller, W., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2024). Synthesis and preclinical evaluation of BOLD-100 radiolabeled with ruthenium-97 and ruthenium-103. Dalton Transactions. Advance online publication. https://doi.org/10.1039/d4dt00118d

Kastner, A., Mendrina, T., Babu, T., Karmakar, S., Poetsch, I., Berger, W., Keppler, B. K., Gibson, D., Heffeter, P., & Kowol, C. R. (2023). Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs. Inorganic Chemistry Frontiers, 11(2), 534-548. https://doi.org/10.1039/d3qi02032k

Baier, D., Mendrina, T., Schoenhacker-Alte, B., Pirker, C., Mohr, T., Rusz, M., Regner, B., Schaier, M., Sgarioto, N., Raynal, N. J. M., Nowikovsky, K., Schmidt, W. M., Heffeter, P., Meier-Menches, S. M., Koellensperger, G., Keppler, B. K., & Berger, W. (2023). The Lipid Metabolism as Target and Modulator of BOLD-100 Anticancer Activity: Crosstalk with Histone Acetylation. Advanced science, 10(32), Article 2301939. https://doi.org/10.1002/advs.202301939

Kastner, A., Schueffl, H., Yassemipour, P. A., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes. Angewandte Chemie - International Edition, 62(46), Article e202311468. https://doi.org/10.1002/anie.202311468

Happl, B., Brandt, M., Balber, T., Benčurová, K., Talip, Z., Voegele, A., Heffeter, P., Kandioller, W., Van der Meulen, N. P., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2023). Synthesis and Preclinical Evaluation of Radiolabeled [¹⁰³Ru]BOLD-100. Pharmaceutics, 15(11), Article 2626. https://doi.org/10.3390/pharmaceutics15112626

Maier, T., Wutschitz, J., Gajic, N., Hejl, M., Cseh, K., Mai, S., Jakupec, M. A., Galanski, M. S., & Keppler, B. K. (2023). Not the usual suspect - an unexpected organometallic product during the synthesis of cytotoxic platinum(II) complexes. Dalton Transactions, 52(44), 16326-16335. https://doi.org/10.1039/d3dt01736b

Lerchbammer-Kreith, Y., Hejl, M., Wenisch, D., Jakupec, M. A., Galanski, M. S., & Keppler, B. K. (2023). Cytotoxic Impact of Fluorinated Ligands in Equatorial Position of Trans-Configured Diam(m)inetetracarboxylatoplatinum(IV) Complexes. Inorganics, 11(10), Article 411. https://doi.org/10.3390/inorganics11100411

Liu, X., Wenisch, D., Dahlke, P., Jordan, P. M., Jakupec, M. A., Kowol, C. R., Liebing, P., Werz, O., Keppler, B. K., & Weigand, W. (2023). Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs. European Journal of Medicinal Chemistry, 257, Article 115515. https://doi.org/10.1016/j.ejmech.2023.115515

Introducing a general cell membrane marker for bioimaging with LA-ICP-TOFMS

Claude Molitor (Speaker), Gabriel Braun (Contributor), Martin Schaier (Contributor), Elisabeth Föls (Contributor), Sarah Theiner (Contributor), Walter Berger (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

19 Nov 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Introducing a general cell membrane marker for bioimaging with LA-ICP-TOFMS

Claude Molitor (Speaker), Gabriel Braun (Contributor), Martin Schaier (Contributor), Elisabeth Föls (Contributor), Sarah Theiner (Contributor), Walter Berger (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

12 Sept 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Introducing a general cell membrane marker for bioimaging with LA-ICP-TOFMS

Claude Molitor (Speaker), Gabriel Braun (Contributor), Martin Schaier (Contributor), Elisabeth Föls (Contributor), Sarah Theiner (Contributor), Walter Berger (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

2 Jul 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

HIGHLY CYTOTOXIC NAPTHOQUINONE DERIVED N,O,O-TRIDENTATE ORGANOMETALLICS AS POTENTIAL ANTICANCER AGENTS

Alexander Rosner (Invited speaker), Lukas Skos (Contributor), Theresa Mendrina (Contributor), Samuel Matthias Meier-Menches (Contributor), Petra Heffeter (Contributor), Wolfgang Kandioller (Contributor) & Bernhard Keppler (Contributor)

23 Jun 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

METAL ISOTOPE PATTERN RECOGNITION IN HIGH-RESOLUTION MASS SPECTROMETRY: UNVEILING THE METABOLOMIC PATHWAYS OF BOLD 100 AND RELATED METAL BASED ISOTOPE PATTERNS

Claude Molitor (Speaker), David Loibnegger (Contributor), Yasin El Abiead (Contributor), Harald Schöny (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

17 Jun 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Translational Metallomics for Metal-based Anti-Cancer Drug Development

David Loibnegger (Speaker), Simone Bräuer (Contributor), Sarah Theiner (Contributor), Gabriel Braun (Contributor), Martin Schaier (Contributor), Elisabeth Föls (Contributor), Claude Molitor (Contributor), Walter Berger (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

17 Jun 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Subcellular imaging of a dual stable isotope-labeled platinum(IV) complex in murine tumor

Anton Legin (Speaker), Christian Kowol (Contributor), Arno Schintlmeister (Contributor), Hemma Schueffl (Contributor), Walter Berger (Contributor), Petra Heffeter (Contributor) & Bernhard Keppler (Contributor)

16 Oct 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Evaluation of two albumin-targeting moieties as in situ binders in comparison to maleimide

Anja Federa (Speaker), H. Schueffl (Contributor), Alexander Kastner (Contributor), Julia Kronberger (Contributor), Bernhard Keppler (Contributor), Thomas Mindt (Contributor), P. Heffeter (Contributor) & Christian Kowol (Contributor)

3 Sept 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Elemental analysis: Essential purity control but prone to manipulations

Wolfgang Kandioller (Contributor), Johannes Theiner (Contributor), Bernhard Keppler (Contributor) & Christian Kowol (Invited speaker)

11 Jun 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Impact of albumin-targeting on the anticancer activity and tumor distribution of platinum(IV) prodrugs

Hemma Schueffl (Contributor), Sarah Theiner (Contributor), Oliver Baumfried (Contributor), Gunda Köllensperger (Contributor), Anton Legin (Contributor), Bernhard Keppler (Contributor), Walter Berger (Contributor), Christian Kowol (Invited speaker) & Petra Heffeter (Speaker)

11 Jun 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Introduction of Bioactive Ligand Scaffolds to Tridentate Organoruthenium Complexes

Alexander Rosner (Speaker), Wolfgang Kandioller (Contributor) & Bernhard Keppler (Contributor)

22 Mar 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Not the Usual Suspect – an Unexpected Organometallic Product during the Synthesis of a Cytotoxic Platinum(II) Complex

Thomas Maier (Speaker), Judith Wutschitz (Contributor), Natalie Gajic (Contributor), Alexander Prado-Roller (Contributor), Michaela Hejl (Contributor), Klaudia Cseh (Contributor), Michael Jakupec (Contributor), Mathea Sophia Galanski (Contributor) & Bernhard Keppler (Contributor)

22 Mar 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS

Andreas Schweikert (Speaker), Sarah Theiner (Contributor), Martin Sala (Contributor), Petra Vician (Contributor), Walter Berger (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

12 Jul 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Impact of albumin-targeting on the pharmacology, tissue distribution and anticancer activity of an oxaliplatin(IV) bismaleimide prodrug in vivo

Hemma Schueffl (Speaker), Sarah Theiner (Contributor), Gunda Köllensperger (Contributor), Bernhard Keppler (Contributor), Walter Berger (Contributor), Christian Kowol (Contributor), Anton Legin (Contributor) & Petra Heffeter (Speaker)

29 Jun 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

99 Jahre Warburg-Effekt und die Entwicklung einer tumorhemmenden Rutheniumverbindung

Bernhard Keppler (Invited speaker)

25 Jun 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

High-resolution and high-speed imaging by LA-ICP-TOFMS

Sarah Theiner (Invited speaker), Andreas Schweikert (Contributor), Oana M. Voloaca (Contributor), Laura M. Cole (Contributor), Malcolm R. Clench (Contributor), Sarah L. Haywood-Small (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

16 Jan 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS

Andreas Schweikert (Speaker), Sarah Theiner (Contributor), Debora Wernitznig (Contributor), Anna Schöberl (Contributor), Martin Schaier (Contributor), Sophie Neumayer (Contributor), Bernhard Keppler (Contributor) & Gunda Köllensperger (Contributor)

11 Jun 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Ionic Liquids: a greener solution for heavy metal removal from aqueous solutions?

Franz Jirsa (Keynote speaker), Philip Pirkwieser (Contributor), Jose A. Lopez-Lopez (Contributor), Michael Schagerl (Contributor), Wolfgang Kandioller (Contributor), Bernhard Keppler (Contributor) & Carlos Moreno (Contributor)

25 Oct 2020

Activity: Talks and presentations › Talk or oral contribution › Science to Science

A Ruthenium and a Gallium Complex in Clinical Trials

Bernhard Keppler (Invited speaker)

15 Nov 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Ionic liquids: a greener alternative for metal extraction from aqueous solutions?

Franz Jirsa (Speaker), Philip Pirkwieser (Contributor), José Antonio López-López (Contributor), Michael Schagerl (Contributor), Wolfgang Kandioller (Contributor), Bernhard Keppler (Contributor) & Carlos Moreno (Contributor)

4 Nov 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Hydrolysis of equatorial ligands of platinum(IV) complexes

Alexander Kastner (Keynote speaker), Isabella Pötsch (Contributor), Petra Heffeter (Contributor), Bernhard Keppler (Contributor) & Christian Kowol (Contributor)

24 Sept 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Molecular profiling of cutaneous melanoma cells and their cerebral metastasis from patient derived mouse xenografts suggest individually distinct adaptation strategies

Benjamin Neuditschko (Speaker), Lukas Janker (Contributor), Laura Niederstätter (Contributor), Julia Brunmair (Contributor), Katharina Krivanek (Contributor), Sivan Izraely (Contributor), Orit Sagi-Assif (Contributor), Tsipi Meshel (Contributor), Bernhard Keppler (Contributor), Giorgia Del Favero (Contributor), Isaac P. Witz (Contributor) & Christopher Gerner (Contributor)

23 Sept 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Metallodrug Strategies in a Changing Environment of Anticancer Drug Development

Bernhard Keppler (Keynote speaker)

15 Aug 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Water-soluble NHC stabilized Gold Nanoparticles

Michael Reithofer (Speaker), Jia Min Chin (Contributor), Adam J. Young (Speaker), Haider Sami (Contributor), Constantin Eisen (Contributor), Guilherme Rubio (Contributor), Nathalie Tepe (Contributor), Thilo Hofmann (Contributor), Manfred Ogris (Contributor) & Bernhard Keppler (Contributor)

11 Aug 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

High resolution LA-ICP-TOF-MS imaging in preclinical metal-based anticancer drug research

Sarah Theiner (Speaker), Andreas Schweikert (Contributor), Anton Legin (Contributor), Debora Wernitznig (Contributor), Stijn J. M. Van Malderen (Contributor), Thibaut Van Acker (Contributor), Bernhard Keppler (Contributor), Frank Vanhaecke (Contributor) & Gunda Köllensperger (Contributor)

26 Jun 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Schwermetallextraktion aus wässrigen Lösungen mithilfe von neuen ionischen Flüssigkeiten

Philip Pirkwieser (Speaker), Jose A. Lopez-Lopez (Contributor), Wolfgang Kandioller (Contributor), Bernhard Keppler (Contributor), Carlos Moreno (Contributor) & Franz Jirsa (Contributor)

9 May 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Multimodal imaging of multicellular tumor spheroids upon metallodrug treatment

Sarah Theiner (Speaker), Gunda Köllensperger (Contributor), Stijn J. M. Van Malderen (Contributor), Thibaut Van Acker (Contributor), M. Holzlechner (Contributor), A. Svirkova (Contributor), Martina Marchetti-Deschmann (Contributor), Anton Legin (Contributor), Bernhard Keppler (Contributor), Frank Vanhaecke (Contributor) & Gunda Köllensperger (Contributor)

8 Jan 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Multimodal imaging of multicellular tumor spheroids by MALDI-MS and high- resolution LA-ICP-MS

Sarah Theiner (Speaker), S. Van Malderen (Contributor), M. Holzlechner (Contributor), A. Svirkova (Contributor), T. Van Acker (Contributor), Anton Legin (Contributor), Michael Jakupec (Contributor), Bernhard Keppler (Contributor), Martina Marchetti-Deschmann (Contributor), Frank Vanhaecke (Contributor) & Gunda Köllensperger (Contributor)

14 Aug 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

On the molecular mechanism of action of organometallic anticancer drugs

Christopher Gerner (Speaker), Samuel Matthias Meier (Contributor), Dominique Kreutz (Contributor), Tamara Weiss (Contributor), Andrea Bileck (Contributor), Bernhard Keppler (Contributor) & Gerhard Wiche (Contributor)

14 Aug 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Post-digestion stabilization of osmium enables quantitation by ICP-MS in cell culture and tissue

Matthias Klose (Speaker), Michaela Hejl (Contributor), Petra Heffeter (Contributor), Michael Jakupec (Contributor), Samuel Matthias Meier (Contributor), Walter Berger (Contributor) & Bernhard Keppler (Contributor)

17 May 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

DNA vs. Protein – Capillary Zone Electrophoresis–Mass Spectrometry to characterize Metallodrug binding Preferences

Christian Artner (Speaker), Hannah U. Holtkamp (Contributor), Christian G. Hartinger (Contributor), Samuel Matthias Meier (Contributor) & Bernhard Keppler (Contributor)

12 May 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Understanding the metabolism of the anticancer drug Triapine by application of electrochemistry and liquid chromatography coupled to mass spectrometry

Karla Pelivan (Speaker), Lisa Frensemeier (Contributor), Uwe Karst (Contributor), Gunda Köllensperger (Contributor), Björn Bielec (Contributor), Petra Heffeter (Contributor), Christian Kowol (Contributor) & Bernhard Keppler (Contributor)

12 May 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

High resolution LA-ICP-MS imaging in three dimensional tumor spheroids

Sarah Theiner (Speaker), S. Van Malderen (Contributor), T. Van Acker (Contributor), Anton Legin (Contributor), Michael Jakupec (Contributor), Bernhard Keppler (Contributor), Frank Vanhaecke (Contributor) & Gunda Köllensperger (Contributor)

19 Feb 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Proteomics for Understanding Metallodrug Effects

Samuel Matthias Meier-Menches (Invited speaker), Dominique Kreutz (Contributor), Bernhard Keppler (Contributor) & Christopher Gerner (Contributor)

4 Dec 2016

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Metalle in der Medizin – neue Möglichkeiten in der Krebstherapie

Bernhard Keppler (Invited speaker)

19 Oct 2016

Activity: Talks and presentations › Talk or oral contribution › Other

Metalle in der Krebsforschung

Bernhard Keppler (Invited speaker)

4 Oct 2016

Activity: Talks and presentations › Talk or oral contribution › Other

Where Do We Stand with Anticancer Ruthenium Complexes?

Bernhard Keppler (Keynote speaker)

30 Aug 2016

Activity: Talks and presentations › Talk or oral contribution › Other

Anticancer Metal Compounds in the Era of Targeted Therapies: Challenges and Approaches

Bernhard Keppler (Invited speaker)

16 Nov 2015

Activity: Talks and presentations › Talk or oral contribution › Other

Development of Metal-based Anticancer Drugs in the Era of Targeted Therapies

Bernhard Keppler (Keynote speaker)

13 Jul 2015

Activity: Talks and presentations › Talk or oral contribution › Other

Recent Advances in Bioinorganic Anticancer Drug Development

Bernhard Keppler (Invited speaker)

25 Sept 2014

Activity: Talks and presentations › Talk or oral contribution › Other

Metal complexes and organometallic compounds in anticancer drug development

Bernhard Keppler (Keynote speaker)

25 Jun 2014

Activity: Talks and presentations › Talk or oral contribution › Other

Preclinical and Clinical Development of an Antitumor Ruthenium Compound (Update)

Bernhard Keppler (Invited speaker)

7 Mar 2014

Activity: Talks and presentations › Talk or oral contribution › Other

Recent Advances with Ruthenium Compounds in Cancer Treatment

Bernhard Keppler (Keynote speaker)

8 Sept 2013

Activity: Talks and presentations › Talk or oral contribution › Other

Metallkomplexe in der Krebstherapie – Gibt es eine Zukunft für Ruthenium in der klinischen Therapie bösartiger Tumoren?

Bernhard Keppler (Invited speaker)

29 May 2013

Activity: Talks and presentations › Talk or oral contribution › Other

Metals in Medicine

Bernhard Keppler (Invited speaker)

13 May 2013

Activity: Talks and presentations › Talk or oral contribution › Other

Structure-activity relationship studies and biological activity of flavonol-derived RuII(arene) anticancer complexes

Bernhard Keppler (Contributor)

7 Dec 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Neue Krebstherapeutika aus dem Bereich der Koordinationschemie

Bernhard Keppler (Invited speaker)

9 Nov 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Pt(IV) bis-, tris- and tetracarboxylato complexes as potentail anticancer drugs: synthesis, analytical, biological, DFT and QSAR studies.

Bernhard Keppler (Contributor)

11 Oct 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Cdk inhibitory activity of organometallic 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines

Bernhard Keppler (Contributor)

12 Sept 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Preclinical and Clinical Advances with Anticancer Metal Compounds

Bernhard Keppler (Invited speaker)

8 Jul 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Development and optimization of multifunctional nanoparticles for molecular imaging and therapy

Bernhard Keppler (Contributor)

28 Jun 2012

Activity: Talks and presentations › Talk or oral contribution › Other

(Thio)pyronederived organometallics: an approach for new metalbased anticancer drugs

Bernhard Keppler (Contributor)

18 Jun 2012

Activity: Talks and presentations › Talk or oral contribution › Other

DNA-binding and Topoisomerase IIa-inhibiting RuII(arene) Complexes with Flavone-derived Ligands

Bernhard Keppler (Contributor)

2 Apr 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Novel tetracarboxylato platinum(IV) complexes as carboplatin prodrugs

Bernhard Keppler (Contributor)

2 Apr 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Neue Protein-Targets in der Krebstherapie am Beispiel GRP 78

Bernhard Keppler (Invited speaker)

5 Mar 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Future Perspectives of Metal Compounds in Cancer Therapy

Bernhard Keppler (Invited speaker)

2 Mar 2012

Activity: Talks and presentations › Talk or oral contribution › Other

Metalle in der Medizin. Von metallhaltigen Enzymen bis zu neuen Krebstherapeutika.

Bernhard Keppler (Speaker)

24 Nov 2011

Activity: Talks and presentations › Talk or oral contribution › Other

Investigational Metal-Based Cancer Therapeutics - Recent Developments

Bernhard Keppler (Invited speaker)

7 Aug 2011

Activity: Talks and presentations › Talk or oral contribution › Other

From coordination compounds to anticancer drugs

Bernhard Keppler (Invited speaker)

15 Jun 2011

Activity: Talks and presentations › Talk or oral contribution › Other

Technologietransfer an der Universität Wien

Bernhard Keppler (Speaker)

19 May 2011

Activity: Talks and presentations › Talk or oral contribution › Other

Combating Cancer with Metal Compounds - Approaches and Perspectives

Bernhard Keppler (Invited speaker)

11 Apr 2011

Activity: Talks and presentations › Talk or oral contribution › Other

Pre-clinical and clinical development of ruthenium and gallium compounds an overview and update

Bernhard Keppler (Invited speaker)

31 Mar 2011

Activity: Talks and presentations › Talk or oral contribution › Other

Entwicklung neuer antitumoraler Metallkomplexe

Bernhard Keppler (Keynote speaker)

5 Oct 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Recent Developments in Investigational Metal-Based Cancer Therapeutics

Bernhard Keppler (Keynote speaker)

24 Jun 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Neue koordinationschemische Strategien zur Entwicklung von Tumortherapeutika

Bernhard Keppler (Invited speaker)

1 Jun 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Investigation of the Binding Interaction of Oxaliplatin to Ubiquitin by Mass Spectrometric Methods

Bernhard Keppler (Contributor)

29 Mar 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Maltol-derived ruthenium(II)-cymene complexes with tumor inhibiting properties: The impact of ligand-metal bond stability on the anticancer activity

Bernhard Keppler (Contributor)

29 Mar 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Metal-Arene Complexes Linked with Carbohydrate Ligands: Cytotoxicity, Hydrolysis and Interaction with Biomolecules

Bernhard Keppler (Contributor)

29 Mar 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Organometallic anticancer compounds targeted by linking the flavopiridol backbone to ruthenium-cymene moieties

Bernhard Keppler (Contributor)

29 Mar 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Synthesis and Cytotoxicity of Metal-Arene Complexes of 3-Hydroxy-2-pyridinone-Derived Ligands

Bernhard Keppler (Contributor)

29 Mar 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Controlling the Reactivity of Anticancer Active Organometallic Compounds

Bernhard Keppler (Contributor)

4 Feb 2010

Activity: Talks and presentations › Talk or oral contribution › Other

Pyrone-derived Ru(II) complexes and their biological activity

Bernhard Keppler (Contributor)

25 Sept 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Terrestrial derived humic substances in aquatic systems: natural chelators for iron linking limnicand marine environments

Bernhard Keppler (Contributor)

24 Aug 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Transport of iron through a bulk liquid membrane containing the ionic liquid trihexyl(tetradecyl)phosphonium chloride

Bernhard Keppler (Contributor)

24 Aug 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Urea- and thiourea-functionalized hydrophobic ionic liquids for silver and platinum extraction from aqueous solutions.

Bernhard Keppler (Contributor)

24 Aug 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Die Rolle der Koordinationschemie in der modernen Medizin am Beispiel neuer Krebstherapeutika

Bernhard Keppler (Invited speaker)

9 Jul 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Von der Koordinationschemie zur Entwicklung neuer Krebstherapeutika

Bernhard Keppler (Invited speaker)

9 Jul 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Tumor-inhibiting Metal Compounds from Bench to Bedside

Bernhard Keppler (Invited speaker)

26 Jun 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Study on novel ionic liquids as extracting agent for priority metals from waste waters

Bernhard Keppler (Contributor)

15 Feb 2009

Activity: Talks and presentations › Talk or oral contribution › Other

Anticancer active RAPTA-C analogues with carbohydrate-based ligands: in vitro anticancer activity and metabolization

Bernhard Keppler (Contributor)

11 Nov 2008

Activity: Talks and presentations › Talk or oral contribution › Other

CONJUGATION OF BIFUNCTIONAL CHELATING AGENTS TO BIOMOLECULES

Bernhard Keppler (Invited speaker)

10 Oct 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Beyond Platinum: Investigational Metallodrugs for Cancer Therapy

Bernhard Keppler (Keynote speaker)

2 Sept 2008

Activity: Talks and presentations › Talk or oral contribution › Other

CONJUGATION OF BIFUNCTIONAL CHELATING AGENTS TO BIOMOLECULES

Bernhard Keppler (Contributor)

31 Aug 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Mono- and Polynuclear Ruthenium-Arene Complexes as Anticancer Agents

Bernhard Keppler (Contributor)

6 Jul 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Development of New Anticancer Metal Complexes from Bench to Bedside

Bernhard Keppler (Keynote speaker)

19 Jun 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Albumin-based nanoparticles for use in theranostics: opportunities and challenges

Bernhard Keppler (Contributor)

26 May 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Structure-activity relationships and DNA platination of new di- and tetracarboxylatoplatinum(IV) complexes

Bernhard Keppler (Contributor)

19 May 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Anticancer-Active Coordination Compounds - New Strategies

Bernhard Keppler (Keynote speaker)

4 Apr 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Neue Strategien zur Entwicklung tumorhemmender Metallkomplexe

Bernhard Keppler (Invited speaker)

1 Apr 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Computational Electrochemistry of Ruthenium Anticancer Agents

Bernhard Keppler (Contributor)

17 Mar 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Osmium(II)/(III)-dmso-azole complexes: synthesis, properties and application

Bernhard Keppler (Contributor)

17 Mar 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Strategies for the Development of Anticancer-Active Coordination Compounds

Bernhard Keppler (Invited speaker)

15 Feb 2008

Activity: Talks and presentations › Talk or oral contribution › Other

Tris(8-quinolinolato)gallium(III) (KP46, FFC11), an investigational anticancer drug in clinical trials

Bernhard Keppler (Contributor)

15 Jul 2007

Activity: Talks and presentations › Talk or oral contribution › Other

XAS investigation of the Ga coordination sphere in solution and in cancer cells treated with KP46

Bernhard Keppler (Contributor)

15 Jul 2007

Activity: Talks and presentations › Talk or oral contribution › Other

Novel strategies to develop new antitumor-active metal compounds

Bernhard Keppler (Speaker)

4 Jul 2007

Activity: Talks and presentations › Talk or oral contribution › Other

Wechselwirkung cytotoxischer dinuklearer Ru(II)-Verbindungen mit Biomolekülen

Bernhard Keppler (Contributor)

1 Jun 2007

Activity: Talks and presentations › Talk or oral contribution › Other

Modulating the in vitro activity of dinuclear ruthenium anticancer compounds. surprisingly high cytotoxicity and weak covalent DNA binding ability

Bernhard Keppler (Contributor)

30 May 2007

Activity: Talks and presentations › Talk or oral contribution › Other

Studies on the interaction of tumor-inhibiting ruthenium complexes with serum proteins by means of capillary electrophoretic and mass spectrometric methods

Bernhard Keppler (Speaker)

17 Jun 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Metalle im Zentrum des Lebens

Bernhard Keppler (Speaker)

7 Jun 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Metallkomplexe in der Tumortherapie

Bernhard Keppler (Speaker)

23 May 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Impact of biological reductants on GMP binding of trans-[RuIIICl4(Hind)2]- and preparation of a model nucleobase adduct

Bernhard Keppler (Contributor)

21 May 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Preclinical and early clinical development of the antitumor gallium complex KP46 (FFC11)

Bernhard Keppler (Contributor)

21 May 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Metalle im Zentrum des Lebens

Bernhard Keppler (Speaker)

20 Apr 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Redoxverhalten und Zytotoxizität der Rutheniumverbindung KP1019 in Gegenwart physiologischer Reduktionsmittel

Bernhard Keppler (Contributor)

10 Apr 2006

Activity: Talks and presentations › Talk or oral contribution › Other

Synthese, Charakterisierung und antiproliferative Aktivität von 2,3-Diaminoglucopyranose-Platin(II)-Komplexen

Bernhard Keppler (Contributor)

10 Apr 2006

Activity: Talks and presentations › Talk or oral contribution › Other

NanoSIMS/EM/CLSM-Imaging

9/03/15 → 9/03/18

Project: Research funding

neuartige Polyphosphazene

14/05/12 → 31/08/16

Project: Research funding

tumorhem.Rutheniumkompl.

18/03/10 → 5/03/13

Project: Research funding

Thiosemikarbazon-Derivate

1/11/09 → 31/10/12

Project: Research funding

Ruthenium-,Platin-,Goldkomple.

1/12/08 → 1/12/11

Project: Research funding

Antitumor-Metallkomplexe

1/05/05 → 30/06/08

Project: Research funding

Nano-MRI

1/01/05 → 30/06/10

Project: Research funding

Department of Inorganic Chemistry

Währinger Straße 42
1090 Wien

T: +43-1-4277-52602

bernhard.keppler@univie.ac.at