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Assoz. Prof. Mag. Dr. Christian Kowol

T: +43-1-4277-52611

christian.kowol@univie.ac.at

http://anorg-chemie.univie.ac.at/research/bioinorganic-chemistry/group-christian-kowol/

Winter term 2024

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270029 PR Basic Chemistry Laboratory Course I - Preparative Lab Course

270186 PR Practical Course Coordination Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

270314 VO Bioinorganic Chemistry

Summer term 2024

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270186 PR Practical Course Coordination Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

Winter term 2023

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270029 PR Basic Chemistry Laboratory Course I - Preparative Lab Course

270186 PR Practical Course Coordination Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

270314 VO Bioinorganic Chemistry

Mosca, E., Federa, A., Pirker, C., Schosserer, M., Liendl, L., Eckhard, M., Sombke, A., Dömötör, O., Kirchhofer, D., Timelthaler, G., Baier, D., Gurschka, P., Gabler, L., Reithofer, M., Chin, J. M., Elsayad, K., Englinger, B., Tahir, A., Kowol, C. R., & Berger, W. (2024). The tyrosine kinase inhibitor Nintedanib induces lysosomal dysfunctionality: Role of protonation-dependent crystallization processes. Chemico-Biological Interactions, 403, Article 111243. https://doi.org/10.1016/j.cbi.2024.111243

Teixeira, R. G., Stefanelli, A., Pilon, A., Warmers, R., Fontrodona, X., Romero, I., Costa, P. J., Villa de Brito, M. J., Hudec, X., Pirker, C., Türck, S., Antunes, A. M. M., Kowol, C. R., Ott, I., Brozovic, A., Sombke, A., Eckhard, M., Tomaz, A. I., Heffeter, P., & Valente, A. (2024). Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands. Journal of Medicinal Chemistry, 67(8), 6081-6098. https://doi.org/10.1021/acs.jmedchem.3c01036

Pósa, V., Federa, A., Cseh, K., Wenisch, D., Spengler, G., May, N. V., Lihi, N., Samu, G. F., Jakupec, M. A., Keppler, B. K., Kowol, C. R., & Enyedy, É. A. (2024). A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions. Inorganic Chemistry, 63(5), 2401-2417. https://doi.org/10.1021/acs.inorgchem.3c03259

Kastner, A., Mendrina, T., Babu, T., Karmakar, S., Poetsch, I., Berger, W., Keppler, B. K., Gibson, D., Heffeter, P., & Kowol, C. R. (2023). Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs. Inorganic Chemistry Frontiers, 11(2), 534-548. https://doi.org/10.1039/d3qi02032k

Kastner, A., Schueffl, H., Yassemipour, P. A., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes. Angewandte Chemie - International Edition, 62(46), Article e202311468. https://doi.org/10.1002/anie.202311468

Liu, X., Wenisch, D., Dahlke, P., Jordan, P. M., Jakupec, M. A., Kowol, C. R., Liebing, P., Werz, O., Keppler, B. K., & Weigand, W. (2023). Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs. European Journal of Medicinal Chemistry, 257, Article 115515. https://doi.org/10.1016/j.ejmech.2023.115515

Schaier, M., Falcone, E., Prstek, T., Vileno, B., Hager, S., Keppler, B. K., Heffeter, P., Koellensperger, G., Faller, P., & Kowol, C. R. (2023). Human serum albumin as a copper source for anticancer thiosemicarbazones. Metallomics, 15(8), Article mfad046. https://doi.org/10.1093/mtomcs/mfad046

Caban, M., Koblmueller, B., Groza, D., Schueffl, H. H., Terenzi, A., Tolios, A., Mohr, T., Mathuber, M., Kryeziu, K., Jaunecker, C., Pirker, C., Keppler, B. K., Berger, W., Kowol, C. R., & Heffeter, P. (2023). A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo. Cancer Letters, 565, Article 216237. https://doi.org/10.1016/j.canlet.2023.216237

Kastner, A., Mendrina, T., Bachmann, F., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs. Inorganic Chemistry Frontiers, 10(14), 4126-4138. https://doi.org/10.1039/d3qi00968h

Strasser, P., Montsch, B., Weiss, S., Sami, H., Kugler, C., Hager, S., Schueffl, H., Mader, R., Brüggemann, O., Kowol, C. R., Ogris, M., Heffeter, P., & Teasdale, I. (2023). Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo. Small, 19(22), Article 2300767. https://doi.org/10.1002/smll.202300767

Mendrina, T., Poetsch, I., Schueffl, H., Baier, D., Pirker, C., Ries, A., Keppler, B. K., Kowol, C. R., Gibson, D., Grusch, M., Berger, W., & Heffeter, P. (2023). Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands. Pharmaceutics, 15(2), Article 677. https://doi.org/10.3390/pharmaceutics15020677

Solta, A., Boettiger, K., Kovacs, I., Lang, C., Megyesfalvi, Z., Ferk, F., Misík, M., Hoetzenecker, K., Aigner, C., Kowol, C. R., Knasmueller, S., Grusch, M., Szeitz, B., Rezeli, M., Dome, B., & Schelch, K. (2023). Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair. Clinical Cancer Research, 29(22), 4644-4659. https://doi.org/10.1158/1078-0432.CCR-23-1795

Liu, X., Barth, M.-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Keppler, B. K., Gibson, D., & Weigand, W. (2022). Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity. Chemistry & Biodiversity, 19(10), Article e202200695. https://doi.org/10.1002/cbdv.202200695

Schwendenwein, A., Boettiger, K., Kovacs, I., Barany, N., Megyesfalvi, Z., Grusch, M., Kowol, C., Rezeli, M., Hoetzenecker, K., Dome, B., & Schelch, K. (2022). EP14.02-00 Cisplatin in Combination with Entinostat exerts Synergistic Antineoplastic Activity in Small Cell Lung Cancer. Journal of thoracic oncology, 17(9), S537-S537.

Posa, V., Stefanelli, A., Nunes, J. H. B., Hager, S., Mathuber, M., May, N., Berger, W., Keppler, B. K., Kowol, C. R., Enyedy, E. A., & Heffeter, P. (2022). Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance. Cancers, 14(18), Article 4455. https://doi.org/10.3390/cancers14184455

Falcone, E., Ritacca, A. G., Hager, S., Schueffl, H., Vileno, B., El Khoury, Y., Hellwig, P., Kowol, C. R., Heffeter, P., Sicilia, E., & Faller, P. (2022). Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH. Journal of the American Chemical Society, 144(32), 14758-14768. https://doi.org/10.1021/jacs.2c05355

Posa, V., Hajdu, B., Toth, G., Domotor, O., Kowol, C. R., Keppler, B. K., Spengler, G., Gyurcsik, B., & Enyedy, E. A. (2022). The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity. Journal of Inorganic Biochemistry, 231, Article 111786. https://doi.org/10.1016/j.jinorgbio.2022.111786

Fronik, P., Gutmann, M., Vician, P., Stojanovic, M., Kastner, A., Heffeter, P., Pirker, C., Keppler, B. K., Berger, W., & Kowol, C. R. (2022). A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance. Communications Chemistry, 5(1), Article 46. https://doi.org/10.1038/s42004-022-00661-z

Liu, X., Wenisch, D., Barth, M.-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Gibson, D., Keppler, B. K., & Weigand, W. (2022). Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions, 51(44), 16824-16835. https://doi.org/10.1039/d2dt02217f

Kandioller, W., Theiner, J., Keppler, B. K., & Kowol, C. R. (2021). Elemental analysis: an important purity control but prone to manipulations. Inorganic Chemistry Frontiers, 9(3), 412-416. https://doi.org/10.1039/d1qi01379c

Site-selectively functionalized Albumin with DFO*-maleimide for 89Zr-radiolabelling yields a metabolically stable nano-PET probe that enables late time-point imaging of tumors in a murine colorectal cancer model

Julia Kronberger (Speaker), Theresa Balber (Contributor), H. Schueffl (Contributor), R. Wahrmann (Contributor), Anja Federa (Contributor), Thomas Wanek (Contributor), Marie Brandt (Contributor), Markus Mitterhauser (Contributor), Christian Kowol (Contributor), Thomas Mindt (Contributor) & P. Heffeter (Contributor)

19 Sept 2024