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Assoz. Prof. Dipl.-Ing. Markus Muttenthaler, PhD
Markus Muttenthaler
T: +43-1-4277-70515
https://www.neuropeptidelab.com/
Winter term 2024
270011 SE Writing of the Bachelor´s Thesis
270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry
270295 VU Chemical Biology
530001 SE Seminar in Chemical Biology for post-graduates
Summer term 2024
270011 SE Writing of the Bachelor´s Thesis
270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry
530001 SE Seminar in Chemical Biology for post-graduates
Winter term 2023
270011 SE Writing of the Bachelor´s Thesis
270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry
270295 VU Chemical Biology
530001 SE Seminar in Chemical Biology for post-graduates
1 - 20 out of 65
Jandl, B., Dighe, S., Baumgartner, M., Makristathis, A., Gasche, C., & Muttenthaler, M. (2024). Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies. Gastroenterology, 167(6), 1098-1112.e5. https://doi.org/10.1053/j.gastro.2024.04.032
Kremsmayr, T., Schober, G., Kaltenböck, M., Hoare, B. L., Brierley, S. M., & Muttenthaler, M. (2024). Oxytocin Analogues for the Oral Treatment of Abdominal Pain. Angewandte Chemie - International Edition. Advance online publication. https://doi.org/10.1002/anie.202415333
Jandl, B., Dighe, S., Gasche, C., Makristathis, A., & Muttenthaler, M. (2024). Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities. Clinical microbiology reviews, 37(3), e0013323. Article 00133-23. https://doi.org/10.1128/cmr.00133-23
Jandl, B., Zheng, R., Muttenthaler, M., & Baell, J. (2024). Novel Diacyl-hydrazide Compounds as Potential Therapeutics for Visceral Leishmaniasis. ACS Omega, 9(35), 37170-37182. https://doi.org/10.1021/acsomega.4c04517
Muttenthaler, M. (2024). CHEMICAL STRATEGIES TO TUNE POTENCY, SELECTIVITY AND STABILITY OF VENOM PEPTIDES. Toxicon, 248, Article 108028.
Perisic, M., Kalaba, P., Keimpema, E., Gruber, C. W., & Muttenthaler, M. (2024). Advanced molecular tools to study the oxytocin receptor. Journal of Peptide Science, 30(Suppl. 2), Article YML05.
Jandl, B., Lang, M., Makristathis, A., Gasche, C., & Muttenthaler, M. (2024). Development of gut-restricted antibiofilm peptides to target gastrointestinal biofilms. Journal of Peptide Science, 30(Suppl. 2), Article 248-P1.134.
Raabe, K., Kalaba, P., Yong, X. L. H., Keimpema, E., Anggono, V., & Muttenthaler, M. (2024). Photocontrollable probes for the investigation of neuropeptide signalling. Journal of Peptide Science, 30(Suppl. 2), Article 382-P1.
Perisic, M., Woolcock, K., Hering, A., Mendel, H., & Muttenthaler, M. (2024). Oxytocin and vasopressin signaling in health and disease. Trends in Biochemical Sciences, 49(4), 361-377. https://doi.org/10.1016/j.tibs.2024.01.010
Kalaba, P., Sanchez de la Rosa, C., Möller, A., Alewood, P. F., & Muttenthaler, M. (2024). Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers. Journal of Medicinal Chemistry, 67(3), 1625-1640. https://doi.org/10.1021/acs.jmedchem.3c01089
Orgler, E., Baumgartner, M., Duller, S., Kumptisch, C., Hausmann, B., Moser, D., Khare, V., Lang, M., Köcher, T., Frick, A., Muttenthaler, M., Makristathis, A., Moissl-Eichinger, C., & Gasche, C. (2024). Archaea influence composition of endoscopically visible ileocolonic biofilms. Gut microbes, 16(1), Article 2359500. https://doi.org/10.1080/19490976.2024.2359500
Muratspahić, E., Deibler, K., Han, J., Tomašević, N., Jadhav, K. B., Olivé-Marti, A. L., Hochrainer, N., Hellinger, R., Koehbach, J., Fay, J. F., Rahman, M. H., Hegazy, L., Craven, T. W., Varga, B. R., Bhardwaj, G., Appourchaux, K., Majumdar, S., Muttenthaler, M., Hosseinzadeh, P., ... Gruber, C. W. (2023). Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor. Nature Communications, 14(1), Article 8064. https://doi.org/10.1038/s41467-023-43718-w
Wirth, U., Raabe, K., Kalaba, P., Keimpema, E., Muttenthaler, M., & König, B. (2023). Photoswitchable Probes of Oxytocin and Vasopressin. Journal of Medicinal Chemistry, 66(21), 14853-14865. https://doi.org/10.1021/acs.jmedchem.3c01415
Perisic, M., Kalaba, P., Keimpema, E., Muttenthaler, M., & Gruber, C. (2023). Development and application of fluorescent oxytocin receptor tracers. British Journal of Pharmacology, 180(Supplement1), 694-694. Article Meeting Abstract: P0984.
Raabe, K., & Muttenthaler, M. (2022). Photoactivatable probes to study long-term memory formation. Journal of Peptide Science, 28(3), Article P443.
Jadhav, K. B., Vellan, P., Niederacher, G., Becker, C. F. W., & Muttenthaler, M. (2022). Recombinant- and semi- synthesis of human trefoil factor 2 (hTFF2) protein and its analogues. Journal of Peptide Science, 28(3), Article P429.
Perisic, M., Kalaba, P., Keimpema, E., Gruber, C., & Muttenthaler, M. (2022). Tracer development for oxytocin receptor imaging. Journal of Peptide Science, 28(3), Article P285.
Hering, A., Emidio, N. B., & Muttenthaler, M. (2022). Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides. Chemical Communications, 58(65), 9100-9103. https://doi.org/10.1039/d2cc03752a
Liu, H., & Muttenthaler, M. (2022). High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer. Biomedicines, 10(7), Article 1595. https://doi.org/10.3390/biomedicines10071595
Hering, A., Jieu, B., Jones, A., & Muttenthaler, M. (2022). Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry. Frontiers in Chemistry, 10, Article 889154. https://doi.org/10.3389/fchem.2022.889154
1 - 20 out of 65

New opportunities for gut-specific oral peptide drug development

Markus Muttenthaler (Invited speaker)

16 Sept 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Oral peptide therapeutics for gut disorders

Markus Muttenthaler (Invited speaker)

13 Sept 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of Molecular Tools to Study the Oxytocin Receptor System

Monika Perisic (Speaker), Predrag Kalaba (Contributor), Isabell Ober (Contributor), Erik Keimpema (Contributor), Christian Gruber (Contributor) & Markus Muttenthaler (Contributor)

12 Sept 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Oral peptide therapeutics for gut disorders

Markus Muttenthaler (Invited speaker)

2 Sept 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

New Avenues in oral peptide drug development for gut disorders

Markus Muttenthaler (Invited speaker)

25 Aug 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Oral gut-specific peptide therapeutics for treating gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

29 Feb 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Oral gut-specific peptide therapeutics for treating gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

27 Feb 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Oral gut-specific peptide therapeutics for treating gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

15 Feb 2024

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker), Michaela Lang (Contributor), Athanasios Makristathis (Contributor), Christoph Gasche (Contributor) & Markus Muttenthaler (Contributor)

24 Nov 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker), Michaela Lang (Contributor), Athanasios Makristathis (Contributor), Christoph Gasche (Contributor) & Markus Muttenthaler (Contributor)

16 Nov 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Bioactive Peptides – From Nature to Tools and Therapeutics

Markus Muttenthaler (Invited speaker)

15 Oct 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker), Michaela Lang (Contributor), Athanasios Makristathis (Contributor), Christoph Gasche (Contributor) & Markus Muttenthaler (Contributor)

15 Oct 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker), Michaela Lang (Contributor), Athanasios Makristathis (Contributor), Christoph Gasche (Contributor) & Markus Muttenthaler (Contributor)

12 Oct 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Trends & opportunities in venom-derived peptide drug development

Markus Muttenthaler (Keynote speaker)

9 Oct 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Dengue NS1 QCM Sensor based on Epitope-imprinted Polymers

K. Sirivibulkovit (Speaker), D. J. Windisch (Contributor), Markus Muttenthaler (Contributor), P. Saetear (Contributor) & Peter Lieberzeit (Contributor)

4 Aug 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-specific peptide therapeutics

Markus Muttenthaler (Invited speaker)

14 Jul 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Towards gut-specific antibiofilm peptides to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker), Michaela Lang (Contributor), Athanasios Makristathis (Contributor), Christoph Gasche (Contributor) & Markus Muttenthaler (Contributor)

7 Jul 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Chemical strategies to target mucosal biofilms in patients with gastrointestinal disorders

Bernhard Jandl (Speaker) & Markus Muttenthaler (Contributor)

27 Apr 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Development of Photoactivatable Neuropeptide Probes

Konstantin Raabe (Speaker), Predrag Kalaba (Contributor), Erik Keimpema (Contributor) & Markus Muttenthaler (Contributor)

22 Mar 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-specific peptide therapeutics

Markus Muttenthaler (Invited speaker)

28 Feb 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-specific peptide therapeutics

Markus Muttenthaler (Speaker)

23 Feb 2023

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Fluorescent peptide tracers for oxytocin receptor visualization

Monika Perisic (Speaker), Predrag Kalaba (Contributor), C.W. Gruber (Contributor) & Markus Muttenthaler (Contributor)

1 Dec 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-specific peptide therapeutics

Markus Muttenthaler (Speaker)

13 Nov 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-stable peptide therapeutics

Markus Muttenthaler (Speaker)

28 Aug 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Molecular strategies to tune venom peptide functionality

Markus Muttenthaler (Keynote speaker)

7 Aug 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-specific peptide therapeutics

Markus Muttenthaler (Invited speaker)

4 Aug 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

From Venoms to Neuropeptides – Molecular Tools for Neuroscience

Markus Muttenthaler (Invited speaker)

16 Jun 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Gut-specific peptide therapeutics

Markus Muttenthaler (Keynote speaker)

29 May 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Molecular strategies to study and treat gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

17 May 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Molecular strategies to study and treat gastrointestinal disorders

Markus Muttenthaler (Invited speaker)

15 May 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Biologically active oxytocin probes allow (sub)-cellular receptor localization

Monika Perisic (Speaker), Predrag Kalaba (Contributor), Erik Keimpema (Contributor), Thomas Kremsmayr (Contributor), Satish Dighe (Contributor), Christian Gruber (Contributor), Katsuhiko Nishimori (Contributor) & Markus Muttenthaler (Contributor)

12 May 2022

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Chemical strategies to tune potency, selectivity and stability of neuropeptides

Markus Muttenthaler (Speaker)

4 Oct 2021

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Exploring natural scaffolds to engineer gut-stable peptide ligands

Thomas Kremsmayr (Speaker), Christian Friedrich Wilhelm Becker (Contributor) & Markus Muttenthaler (Contributor)

5 Dec 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Disulfide bonds – folding, stability and mimetics

Markus Muttenthaler (Invited speaker)

5 Sept 2019

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Multivalent Ligand Design – Chemistry and Applications

Markus Muttenthaler (Speaker)

3 Dec 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Chemical strategies to tune potency, selectivity and stability of neuropeptides

Markus Muttenthaler (Speaker)

28 Nov 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Recombinant synthesis and purification of hTFF2 protein in S. Cerevisiae

Kirtikumar Bhaskarrao Jadhav (Speaker), Gerhard Niederacher (Contributor) & Markus Muttenthaler (Contributor)

26 Aug 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

From venoms to drugs

Markus Muttenthaler (Invited speaker)

25 Jun 2018

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Neuropeptide Research – From Molecular Probes to Therapeutic Leads

Markus Muttenthaler (Invited speaker)

30 Oct 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Multivalent Ligand Design – Chemistry and Applications

Markus Muttenthaler (Speaker)

12 Oct 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Molecular probe development for the Oxytocin/Vasopressin signalling system - from nature’s blueprints to chemical engineering’

Markus Muttenthaler (Invited speaker)

27 Jul 2017

Activity: Talks and presentations › Talk or oral contribution › Science to Science

Department of Biological Chemistry

Währinger Straße 38-42
1090 Wien
Room: 1H38

T: +43-1-4277-70515

markus.muttenthaler@univie.ac.at