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Univ.-Prof. Dipl.-Ing. Markus Muttenthaler, PhD

T: +43-1-4277-70515

markus.muttenthaler@univie.ac.at

https://www.neuropeptidelab.com/

Sommersemester 2026

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

530001 SE Seminar in Chemical Biology for post-graduates

Wintersemester 2025

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270137 PR Wahlbeispiele Peptid- und Proteinchemie

270295 VU Chemische Biologie

530001 SE Seminar in Chemical Biology for post-graduates

Sommersemester 2025

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270137 PR Wahlbeispiele Peptid- und Proteinchemie

530001 SE Seminar in Chemical Biology for post-graduates

Sirivibulkovit, K., Voelkle, J., Windisch, D. J., Muttenthaler, M., Lieberzeit, P. A., & Saetear, P. (2025). Electrochemical dengue sensor based on NS1 epitope-imprinted polymers. Biosensors and Bioelectronics, 289, Artikel 117915. https://doi.org/10.1016/j.bios.2025.117915

Fernandez-Carrasco, I., Moral-Sanz, J., Kurdyukov, S., Monne, È. O., Hartmann, L. M., Magalhães Novais, S. C., Waller, M. A., McKinnon, N., Chung, F., Salazar Castejón, F. J., Rainho, D. P., Dekan, Z., Kremsmayr, T., Jandl, B., Filipič, K. E., Pamplona, R., Jové, M., Fernandez-Rojo, M. A., Anderluh, G., ... Ikonomopoulou, M. P. (2025). The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions. Cell Death Discovery, 11(1), Artikel 538. https://doi.org/10.1038/s41420-025-02817-x

Perisic Böhm, M., Kalaba, P., Gormal, R. S., Zupančič, M., Wolf, A., Juračić, M., Kremsmayr, T., Meunier, F. A., Langer, T., Gruber, C. W., Keimpema, E., & Muttenthaler, M. (2025). Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization. Angewandte Chemie (International ed. in English), 64(46), e202515180. Artikel e202515180. https://doi.org/10.1002/anie.202515180

Pascali, G., Parmar, A., Zanoni, S., Arthur, A., Hering, A., Teakle, N., Markham, J., Zhang, B., Mackay, T., Klenner, M., Spare, L., Greguric, I., McDonald, A., Bjelosevic, A., Matesic, L., Rahardjo, G., Zahra, D., Hamze, H., Hickie, I. B., ... Guastella, A. J. (2025). Development and characterisation of novel oxytocin analogues for PET imaging. Communications Chemistry, 8(1), 328. https://doi.org/10.1038/s42004-025-01649-1

Gattringer, J., Hasinger, S., Weidmann, A., Walczewska-Szewc, K., Jadhav, K. B., Zrzavy, T., Steinmaurer, A., Baeten, P., Perisic Böhm, M., Cochrane, W., Muttenthaler, M., Broux, B., Gotthardt, D., Rosengren, K. J., Gruber, C. W., & Hellinger, R. (2025). Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching. Journal of Medicinal Chemistry, 68(16), 17202-17220. https://doi.org/10.1021/acs.jmedchem.5c00677

Kerčmar, J., Murko, N., Križančić Bombek, L., Paradiž Leitgeb, E., Pfabe, J., Postić, S., Huang, Y.-C., Stožer, A., Korošak, D., Kozisek, X., Perisic Böhm, M., Muttenthaler, M., Gruber, C. W., & Slak Rupnik, M. (2025). Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses. eLife. https://doi.org/10.7554/elife.106679.1

Ostrovitsa, N., Williams, C., Raabe, K., McLean, J. T., Muttenthaler, M., & Scanlan, E. M. (2025). An Efficient Thiol-ene Mediated Protocol for Thiolated Peptide Synthesis and On-Resin Diversification. Chemistry: A European Journal, 31(36), Artikel e202501372. Vorzeitige Online-Publikation. https://doi.org/10.1002/chem.202501372

Elmaci, D. N., Hopping, G., Hoffmann, W., Muttenthaler, M., & Stein, M. (2025). The structural integrity of human TFF1 under reducing conditions. Redox biology, 81, Artikel 103534. https://doi.org/10.1016/j.redox.2025.103534

Murko, N., Kercmar, J., Bombek, LK., Leitgeb, EP., Postic, S., Pfabe, J., Huang, YC., Stozer, A., Korosak, D., Kozisek, X., Perisic, M., Muttenthaler, M., Gruber, CW., & Rupnik, MS. (2025). Effects of Arginine Vasopressin on Pancreatic α and β Cells: Glucose-Dependent Modulation and Receptor-Specific Responses. Acta physiologica, 241(Supplement735), Artikel Meeting AbstractA 09-12.

Kremsmayr, T., Schober, G., Kaltenböck, M., Hoare, B. L., Brierley, S. M., & Muttenthaler, M. (2024). Oxytocin Analogues for the Oral Treatment of Abdominal Pain. Angewandte Chemie - International Edition, 63(52), Artikel e202415333. https://doi.org/10.1002/anie.202415333

Jandl, B., Dighe, S., Baumgartner, M., Makristathis, A., Gasche, C., & Muttenthaler, M. (2024). Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies. Gastroenterology, 167(6), 1098-1112.e5. https://doi.org/10.1053/j.gastro.2024.04.032

Jandl, B., Dighe, S., Gasche, C., Makristathis, A., & Muttenthaler, M. (2024). Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities. Clinical microbiology reviews, 37(3), Artikel e00133-23. https://doi.org/10.1128/cmr.00133-23

Jandl, B., Zheng, R., Muttenthaler, M., & Baell, J. (2024). Novel Diacyl-hydrazide Compounds as Potential Therapeutics for Visceral Leishmaniasis. ACS Omega, 9(35), 37170-37182. https://doi.org/10.1021/acsomega.4c04517

Muttenthaler, M. (2024). CHEMICAL STRATEGIES TO TUNE POTENCY, SELECTIVITY AND STABILITY OF VENOM PEPTIDES. Toxicon, 248, Artikel 108028.

Perisic, M., Kalaba, P., Keimpema, E., Gruber, C. W., & Muttenthaler, M. (2024). Advanced molecular tools to study the oxytocin receptor. Journal of Peptide Science, 30(Suppl. 2), Artikel YML05.

Jandl, B., Lang, M., Makristathis, A., Gasche, C., & Muttenthaler, M. (2024). Development of gut-restricted antibiofilm peptides to target gastrointestinal biofilms. Journal of Peptide Science, 30(Suppl. 2), Artikel 248-P1.134.

Raabe, K., Kalaba, P., Yong, X. L. H., Keimpema, E., Anggono, V., & Muttenthaler, M. (2024). Photocontrollable probes for the investigation of neuropeptide signalling. Journal of Peptide Science, 30(Suppl. 2), Artikel 382-P1.

Perisic, M., Woolcock, K., Hering, A., Mendel, H., & Muttenthaler, M. (2024). Oxytocin and vasopressin signaling in health and disease. Trends in Biochemical Sciences, 49(4), 361-377. https://doi.org/10.1016/j.tibs.2024.01.010

Kalaba, P., Sanchez de la Rosa, C., Möller, A., Alewood, P. F., & Muttenthaler, M. (2024). Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers. Journal of Medicinal Chemistry, 67(3), 1625-1640. https://doi.org/10.1021/acs.jmedchem.3c01089

Orgler, E., Baumgartner, M., Duller, S., Kumptisch, C., Hausmann, B., Moser, D., Khare, V., Lang, M., Köcher, T., Frick, A., Muttenthaler, M., Makristathis, A., Moissl-Eichinger, C., & Gasche, C. (2024). Archaea influence composition of endoscopically visible ileocolonic biofilms. Gut microbes, 16(1), Artikel 2359500. https://doi.org/10.1080/19490976.2024.2359500

Photocaged neuropeptides for precision studies

Raabe, K. (Vortragende*r), Kalaba, P. (Autor*in), Yong, X. L. H. (Autor*in), Crudeli, G. (Autor*in), Melzer, S. (Autor*in), Keimpema, E. (Autor*in), Anggono, V. (Autor*in) & Muttenthaler, M. (Autor*in)

5 Dez. 2025