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Assoz. Prof. Dr. Thomas Mindt, Privatdoz.

T: +43-1-4277-52690

thomas.mindt@univie.ac.at

https://mindt-group.univie.ac.at/

Summer term 2024

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270041 VO Medical Radiochemistry II - Tracer Development - from Bench to Bed

270165 VO Chemistry of Actinides

270186 PR Practical Course Coordination Chemistry

270192 PR Practical Course Radiopharmaceutical Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

530014 SE PhD / MSc Seminar Radiopharmaceutical Chemistry

530015 SE Journal Club Radiopharmaceutical Chemistry

Winter term 2023

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270015 VO Medical Radio Chemistry 1 - Medicinal Radiochemistry I

270054 VO General Chemistry A

270186 PR Practical Course Coordination Chemistry

270192 PR Practical Course Radiopharmaceutical Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

270315 VO Radioactive Metals in Medicine

530014 SE PhD / MSc Seminar Radiopharmaceutical Chemistry

530015 SE Journal Club Radiopharmaceutical Chemistry

Summer term 2023

270011 SE Writing of the Bachelor´s Thesis

270012 PR Elective Laboratory Course for Bachelor Module - Organic/Bioanorganic/Biological/Biophysical Chemistry

270041 VO Medical Radiochemistry II - Tracer Development - from Bench to Bed

270165 VO Chemistry of Actinides

270192 PR Practical Course Radiopharmaceutical Chemistry

270304 PR Practical Course Bio Inorganic Chemistry

530014 SE PhD / MSc Seminar Radiopharmaceutical Chemistry

530015 SE Journal Club Radiopharmaceutical Chemistry

Guarrochena, X., Kanellopoulos, P., Stingeder, A., Rečnik, L. M., Feiner, I. V. J., Brandt, M., Kandioller, W., Maina, T., Nock, B. A., & Mindt, T. L. (2024). Amide-to-Triazole Switch in Somatostatin-14-Based Radioligands: Impact on Receptor Affinity and In Vivo Stability. Pharmaceutics, 16(3), [392]. https://doi.org/10.3390/pharmaceutics16030392

Guarrochena, X., Kronberger, J., Tieber, M., Ciesielski, P., Mindt, T. L., & Feiner, I. V. J. (2024). Straightforward Synthesis of DFO* - An Octadentate Chelator for Zirconium-89. ChemMedChem, 19(3), [e202300495]. https://doi.org/10.1002/cmdc.202300495

Happl, B., Balber, T., Heffeter, P., Denk, C., Welch, J. M., Köster, U., Alliot, C., Bonraisin, A. C., Brandt, M., Haddad, F., Sterba, J. H., Kandioller, W., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2024). Synthesis and preclinical evaluation of BOLD-100 radiolabeled with ruthenium-97 and ruthenium-103. Dalton Transactions. https://doi.org/10.1039/d4dt00118d

Schmitl, S., Raitanen, J., Witoszynskyj, S., Patronas, E. M., Nics, L., Ozenil, M., Weissenböck, V., Mindt, T. L., Hacker, M., Wadsak, W., Brandt, M. R., & Mitterhauser, M. (2023). Quality Assurance Investigations and Impurity Characterization during Upscaling of [¹⁷⁷Lu]Lu-PSMA^I&T. Molecules, 28(23), [7696]. https://doi.org/10.3390/molecules28237696

Happl, B., Brandt, M., Balber, T., Benčurová, K., Talip, Z., Voegele, A., Heffeter, P., Kandioller, W., Van der Meulen, N. P., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2023). Synthesis and Preclinical Evaluation of Radiolabeled [¹⁰³Ru]BOLD-100. Pharmaceutics, 15(11), [2626]. https://doi.org/10.3390/pharmaceutics15112626

Wang, Y., Felder, P. S., Mesdom, P., Blacque, O., Mindt, T. L., Cariou, K., & Gasser, G. (2023). Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy. ChemBioChem, 24(19), [e202300467]. https://doi.org/10.1002/cbic.202300467

Guarrochena, X., Kaudela, B., & Mindt, T. L. (2023). Automated solid-phase synthesis of metabolically stabilized triazolo-peptidomimetics. Journal of Peptide Science, 29(9), [e3488]. https://doi.org/10.1002/psc.3488

Wang, Y., Staudinger, J. N., Mindt, T. L., & Gasser, G. (2023). Theranostics with photodynamic therapy for personalized medicine: to see and to treat. Theranostics, 13(15), 5501-5544. https://doi.org/10.7150/thno.87363

Jouini, N., Cardinale, J., & Mindt, T. L. (2022). Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD-L1. ChemMedChem, 17(12), [e202200091]. https://doi.org/10.1002/cmdc.202200091

Rischka, L., Vraka, C., Pichler, V., Rasul, S., Nics, L., Gryglewski, G., Handschuh, P., Murgas, M., Godbersen, G. M., Silberbauer, L. R., Unterholzner, J., Wotawa, C., Haider, A., Ahmed, H., Schibli, R., Mindt, T., Mitterhauser, M., Wadsak, W., Hahn, A., ... Ametamey, S. M. (2022). First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-D-aspartate Receptor with (R)-C-11-Me-NB1. Journal of Nuclear Medicine, 63(6), 936-941. https://doi.org/10.2967/jnumed.121.262427

Giammei, C., Jouini, N., Brandt, M. R., Frey, S., Mindt, T. L., & Cardinale, J. (2022). Unexpected transformation of n.c.a. [ ¹¹¹In]InCl ₃ in stock solutions into an unreactive [ ¹¹¹In]In-species. Applied Radiation and Isotopes, 180, [110037]. https://doi.org/10.1016/j.apradiso.2021.110037

Rischka, L., Murgaš, M., Pichler, V., Vraka, C., Rausch, I., Winkler, D., Nics, L., Rasul, S., Silberbauer, L. R., Reed, M. B., Godbersen, G. M., Unterholzner, J., Handschuh, P., Gryglewski, G., Mindt, T., Mitterhauser, M., Hahn, A., Ametamey, S. M., Wadsak, W., ... Hacker, M. (2022). Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[¹¹C]Me-NB1. EJNMMI Research, 12(1), [53]. https://doi.org/10.1186/s13550-022-00925-8

Klasen, B., Lemcke, D., Mindt, T. L., Gasser, G., & Roesch, F. (2021). Development and in vitro evaluation of new bifunctional ⁸⁹Zr-chelators based on the 6-amino-1,4-diazepane scaffold for immuno-PET applications. Nuclear Medicine and Biology, 102-103, 12-23. https://doi.org/10.1016/j.nucmedbio.2021.06.007

Rischka, L., Vraka, C., Pichler, V., Rasul, S., Nics, L., Gryglewski, G., Handschuh, P., Murgas, M., Godbersen, G. M., Silberbauer, L. R., Unterholzner, J., Wotawa, C., Haider, A., Ahmed, H., Schibli, R., Mindt, T., Mitterhauser, M., Wadsak, W., Hahn, A., ... Ametamey, S. M. (2021). First-in-human mapping of the GluN2B subunits of the N-methyl-D-aspartate receptor using (R)-[(11)Cc]Me-NB1 and PET. European Journal of Nuclear Medicine and Molecular Imaging, 48(SUPPL 1), 296.

Feiner, I. V. J., Brandt, M., Cowell, J., Demuth, T., Vugts, D., Gasser, G., & Mindt, T. L. (2021). The Race for Hydroxamate-Based Zirconium-89 Chelators. Cancers, 13(17), [4466]. https://doi.org/10.3390/cancers13174466

Grob, N. M., Schibli, R., Behe, M., & Mindt, T. L. (2021). Improved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin Lu-177-PP-F11N. Cancers, 13(11), [2629]. https://doi.org/10.3390/cancers13112629

Grob, N. M., Schibli, R., Behe, M., Valverde, I. E., & Mindt, T. L. (2021). 1,5-Disubstituted 1,2,3-Triazoles as Amide Bond Isosteres Yield Novel Tumor-Targeting Minigastrin Analogs. ACS Medicinal Chemistry Letters , 12(4), 585-592. https://doi.org/10.1021/acsmedchemlett.0c00636

Vrettos, E., Valverde, I. E., Mascarin, A., Pallier, P. N., Cerofolini, L., Fragai, M., Parigi, G., Hirmiz, B., Bekas, N., Grob, N. M., Shaye, H., Del Borgo, M., Aguilar, M., Magnani, F., Syed, N., Crook, T., Waqif, E., Ghazaly, E., Cherezov, V., ... Stylos, E. K. (2020). Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity. Chemistry: A European Journal, 26(47), 10690-10694. https://doi.org/10.1002/chem.202000924

Recnik, L-M., Kandioller, W., & Mindt, T. L. (2020). 1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity. Molecules, 25(16), [3576]. https://doi.org/10.3390/molecules25163576

Brandt, M., Cowell, J., Aulsebrook, M. L., Gasser, G., & Mindt, T. L. (2020). Radiolabelling of the octadentate chelators DFO* and oxoDFO* with zirconium-89 and gallium-68. Journal of Biological Inorganic Chemistry, 25, 789-796. https://doi.org/10.1007/s00775-020-01800-4