Vortrag im Rahmen des Institutsseminars Biologische Chemie

Associate Professor Raymond Moellering, Department of Chemistry, University of Chicago

Activity Mapping from Single-Cells to Whole Organisms in Cancer

Biological systems are inherently and profoundly heterogeneous, both at the molecular level (e.g., encoded proteins existing in distinct posttranslational modification states and macromolecular complexes) and the cellular level (e.g., intra- and intercellular localization of biomolecules). Despite growing awareness and appreciation for this level of molecular complexity in living systems, most studies still rely on reductionist strategies to interrogate the proteome, owing to the significant technical challenges associated with studying protein structure, function and organization in native environments. We believe that in order to understand molecular information flow under basal or diseased conditions we must be able to probe biomolecular function and organization in native environments across scales of space and time. Therefore, innovation in the development probes and technology platforms is needed. In this talk I will describe the development of new chemical probes and complementary proteomic platforms that enable quantitative detection of protein functional states - including enzymatic activity, protein-protein interaction partners, and the functional consequences of posttranslational modification states – on length scales ranging from single-cells to live animals. I will discuss the integration of these platforms for the discovery, high-throughput profiling and diagnostic detection of enzyme activities associated with tumor progression and metastasis. Beyond cancer, this talk will emphasize the integration of chemical proteomic platforms as a discovery engine to identify novel targets for diagnostic and therapeutic development in human disease.

Dr. Moellering is an Associate Professor of Chemistry at the University of Chicago. He obtained Bachelor’s degrees in Chemistry and Biochemistry & Molecular Biophysics from the University of Arizona. He then earned a Ph.D. in Chemistry at Harvard University as an American Association for Cancer Research Centennial Fellow, followed by postdoctoral training as a Damon Runyon Postdoctoral Fellow at The Scripps Research Institute. Dr. Moellering started his independent program at UChicago in 2015, where his laboratory is focused on developing novel chemical probes and complementary proteomic technologies to expose and exploit novel signaling mechanisms in diseases like cancer, diabetes, and chronic inflammatory conditions. Dr. Moellering’s independent program has garnered recognition with awards that include the Damon Runyon Dale F. Frey Award for Breakthrough Scientists, V Foundation V Scholar Award, American Cancer Society Research Scholar Award, NSF CAREER Award, Sloan Fellowship, and NIH Pathway to Independence and Director’s New Innovator Awards.

Join Zoom Meeting

https://univienna.zoom.us/j/93596141162?pwd=R29VT25UWHF6MkJyZFZwdkwrdkdFUT09

Meeting ID: 935 9614 1162

Kenncode: 499512