RNA Arrays: The Next Generation

10.08.2020

The FWF has recently awarded Jory Lietard from the Department of Inorganic Chemistry with funding for his international project "RNA Arrays: The Next Generation". It aims at establishing a novel approach for the synthesis of very large libraries of RNA sequences of high quality, matching the throughput and efficiency of high-density DNA microarray synthesis developed and improved in the Nucleic Acid Chemistry group.

Access to vast RNA sequence diversity in a single synthesis will be useful for studying RNA aptamer binding landscape and will, in addition, bring us closer to direct sequencing of chemically-made RNA libraries. This project will be a French-Austrian collaboration between Jory Lietard of the University of Vienna and Françoise Debart of the University of Montpellier.

This project will be a French-Austrian collaboration between Jory Lietard and Françoise Debart of the University of Montpellier, and was granted a total funding of around EUR 640,000, of which EUR 400,000 go to Lietard and EUR 240,000 to France through the ANR (Agence Nationale de la Recherche). The team in Montpellier will prepare new RNA building blocks, which will then be incorporated into RNA oligonucleotides using microarray photolithography, here at the Department. Jory  Lietard will take the role of principal investigator for his first FWF-granted project.

Chemist Jory Lietard will take the role of principal investigator for his first FWF-granted project. (Copyright: Faculty of Chemistry)