A pretreatment-free fluorescence-sensing platform for intact exosomes was prepared by a novel chemical nanoprocessing based on molecular imprinting and post-imprinting modifications, wherein antibodies and fluorescent reporter molecules were aligned inside exosome-binding cavities, enabling it to achieve ca. 1000-times higher sensitivity than commercial ELISA without pretreatments.

Toshifumi Takeuchi received his Ph.D. degree in 1984 from Toyama Medical and Pharmaceutical University, Toyama, Japan. Since 2003, he has been a full professor of Kobe University. Prior to that, he was an assistant professor at Nihon University, a post-doctoral fellow at University of Delaware and University of Hawaii at Manoa, an associate professor in the University of Tokyo, and a full professor of Hiroshima City University. His research interests include design and synthesis of molecularly imprinted polymers and their analytical and biomedical applications.