Es handelt sich um die folgende Publikation:
Klose, M.H.M.; Theiner, S.; Varbanov, H.P.; Hoefer, D.; Pichler, V.; Galanski, M.; Meier-Menches, S.M.; Keppler, B.K. Development and Validation of Liquid Chromatography-Based Methods to Assess the Lipophilicity of Cytotoxic Platinum(IV) Complexes. Inorganics 2018, 6, 130.
Lipophilicity is a crucial parameter in drug discovery research because it significantly affects the diffusion of drugs through cell membranes, and thus their cellular accumulation. The publication presents a simple chromatographic method to determine the lipophilicity of cytotoxic platinum(IV) complexes, which can easily be expanded also to other metal-based compounds.