Detailansicht

Burger, I., Schmal, M., Peikert, K., Fourtis, L., Suster, C., Stanetty, C., Schnalzer, D., Hufnagel, B., Böttcher, T., Birner-Gruenberger, R., Mach, R. L., Mach-Aigner, A. R., Schittmayer, M., & Zimmermann, C. (2025). Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. Biotechnology for biofuels and bioproducts, 18(1), 32. https://doi.org/10.1186/s13068-025-02628-3

Pereira, F. C., Ge, X., Kristensen, J. M., Kirkegaard, R. H., Maritsch, K., Szamosvári, D., Imminger, S., Seki, D., Shazzad, J. B., Zhu, Y., Decorte, M., Hausmann, B., Berry, D., Wasmund, K., Schintlmeister, A., Böttcher, T., Cheng, J.-X., & Wagner, M. (2024). The Parkinson's disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration. Nature Microbiology, 9(12), 3165–3183. https://doi.org/10.1038/s41564-024-01853-0

Steuer, J., Sinn, M., Eble, F., Rütschlin, S., Böttcher, T., Hartig, J. S., & Peter, C. (2024). Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch. NAR Genomics and Bioinformatics, 6(3), Artikel lqae132. https://doi.org/10.1093/nargab/lqae132

Savchenko, V., Jaegers, M., Rasche, R., Herrmann, E., König, S., Kümmel, D., Böttcher, T., Fetzner, S., & Ernst, S. (2024). Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis. Cell Reports Physical Science, 5(8), Artikel 102100. https://doi.org/10.1016/j.xcrp.2024.102100

Mou, S., Savchenko, V., Filz, V., Böttcher, T., & DeShazer, D. (2024). Burkholderia pseudomallei produces 2-alkylquinolone derivatives important for host virulence and competition with bacteria that employ naphthoquinones for aerobic respiration. Frontiers in Microbiology, 15, Artikel 1474033. https://doi.org/10.3389/fmicb.2024.1474033

Savchenko, V., Szamosvári, D., Bao, Y., Pignitter, M., & Böttcher, T. (2023). Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response. Communications Chemistry, 6(1), Artikel 138. https://doi.org/10.1038/s42004-023-00937-y

Ückert, A. K., Rütschlin, S., Gutbier, S., Wörz, N. C., Miah, M. R., Martins, A. C., Hauer, I., Holzer, A. K., Meyburg, B., Mix, A. K., Hauck, C., Aschner, M., Böttcher, T., & Leist, M. (2023). Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration. Environment International, 180, Artikel 108229. https://doi.org/10.1016/j.envint.2023.108229

Szamosvari, D., Savchenko, V., Badouin, N., & Böttcher, T. (2023). Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif. Organic & Biomolecular Chemistry, 21(25), 5158-5163. https://doi.org/10.1039/d3ob00710c

Klein, K., Garkov, D., Rütschlin , S., Böttcher, T., & Schreiber, F. (2021). QSDB—a graphical Quorum Sensing Database. Database: The Journal of Biological Databases and Curation, 2021, Artikel baab058. https://doi.org/10.1093/database/baab058

Klein, K., Garkov, D., Ruetschlin, S., Boettcher, T., & Schreiber, F. (2021). QSDB-a graphical Quorum Sensing Database (vol 2021, baab058, 2021). Database: The Journal of Biological Databases and Curation, 2021, Artikel baab071. https://doi.org/10.1093/database/baab071

Böttcher, T., Nguyen , T. H. N., & Szamosvari, D. (2021). Synthesis of bacterial 2-alkyl-4(1H)-quinolone derivatives. ARKIVOC, 2021(9), 218-239. https://doi.org/10.24820/ark.5550190.p011.547

Jancheva, M., & Boettcher, T. (2021). A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus. Journal of the American Chemical Society, 143(22), 8344-8351. https://doi.org/10.1021/jacs.1c01275

Prothiwa, M., Filz, V., Oehler, S., & Boettcher, T. (2021). Inhibiting quinolone biosynthesis of Burkholderia. Chemical Science, 12(20), 6908-6912. https://doi.org/10.1039/d0sc06167k

Penalver, L., Schmid, P., Szamosvari, D., Schildknecht, S., Globisch, C., Sawade, K., Peter, C., & Boettcher, T. (2021). A Ligand Selection Strategy Identifies Chemical Probes Targeting the Proteases of SARS-CoV-2. Angewandte Chemie (International Edition), 60(12), 6799-6806. https://doi.org/10.1002/anie.202016113

Boettcher, T. (2020). Unveiling the Hidden Theatre of Microbes. ChemBioChem: a european journal of chemical biology, 21(20), 2869-2869. https://doi.org/10.1002/cbic.202000554

Szamosvari, D., Prothiwa, M., Dieterich, C. L., & Boettcher, T. (2020). Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. Chemical Communications, 56(47), 6328-6331. https://doi.org/10.1039/d0cc02498h