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Assoz. Prof. Mag. Dr. Christian Kowol

T: +43-1-4277-52611

christian.kowol@univie.ac.at

http://anorg-chemie.univie.ac.at/research/bioinorganic-chemistry/group-christian-kowol/

Wintersemester 2024

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270029 PR Chemisches Grundpraktikum I - präparative Laborübungen

270186 PR Praktikum Koordinationschemie

270304 PR Praktikum Bioanorganische Chemie

270314 VO Bioanorganische Chemie

Sommersemester 2024

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270186 PR Praktikum Koordinationschemie

270304 PR Praktikum Bioanorganische Chemie

Wintersemester 2023

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270029 PR Chemisches Grundpraktikum I - präparative Laborübungen

270186 PR Praktikum Koordinationschemie

270304 PR Praktikum Bioanorganische Chemie

270314 VO Bioanorganische Chemie

Mosca, E., Federa, A., Pirker, C., Schosserer, M., Liendl, L., Eckhard, M., Sombke, A., Dömötör, O., Kirchhofer, D., Timelthaler, G., Baier, D., Gurschka, P., Gabler, L., Reithofer, M., Chin, J. M., Elsayad, K., Englinger, B., Tahir, A., Kowol, C. R., & Berger, W. (2024). The tyrosine kinase inhibitor Nintedanib induces lysosomal dysfunctionality: Role of protonation-dependent crystallization processes. Chemico-Biological Interactions, 403, Artikel 111243. https://doi.org/10.1016/j.cbi.2024.111243

Teixeira, R. G., Stefanelli, A., Pilon, A., Warmers, R., Fontrodona, X., Romero, I., Costa, P. J., Villa de Brito, M. J., Hudec, X., Pirker, C., Türck, S., Antunes, A. M. M., Kowol, C. R., Ott, I., Brozovic, A., Sombke, A., Eckhard, M., Tomaz, A. I., Heffeter, P., & Valente, A. (2024). Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands. Journal of Medicinal Chemistry, 67(8), 6081-6098. https://doi.org/10.1021/acs.jmedchem.3c01036

Pósa, V., Federa, A., Cseh, K., Wenisch, D., Spengler, G., May, N. V., Lihi, N., Samu, G. F., Jakupec, M. A., Keppler, B. K., Kowol, C. R., & Enyedy, É. A. (2024). A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions. Inorganic Chemistry, 63(5), 2401-2417. https://doi.org/10.1021/acs.inorgchem.3c03259

Kastner, A., Mendrina, T., Babu, T., Karmakar, S., Poetsch, I., Berger, W., Keppler, B. K., Gibson, D., Heffeter, P., & Kowol, C. R. (2023). Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs. Inorganic Chemistry Frontiers, 11(2), 534-548. https://doi.org/10.1039/d3qi02032k

Kastner, A., Schueffl, H., Yassemipour, P. A., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes. Angewandte Chemie - International Edition, 62(46), Artikel e202311468. https://doi.org/10.1002/anie.202311468

Liu, X., Wenisch, D., Dahlke, P., Jordan, P. M., Jakupec, M. A., Kowol, C. R., Liebing, P., Werz, O., Keppler, B. K., & Weigand, W. (2023). Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs. European Journal of Medicinal Chemistry, 257, Artikel 115515. https://doi.org/10.1016/j.ejmech.2023.115515

Schaier, M., Falcone, E., Prstek, T., Vileno, B., Hager, S., Keppler, B. K., Heffeter, P., Koellensperger, G., Faller, P., & Kowol, C. R. (2023). Human serum albumin as a copper source for anticancer thiosemicarbazones. Metallomics, 15(8), Artikel mfad046. https://doi.org/10.1093/mtomcs/mfad046

Caban, M., Koblmueller, B., Groza, D., Schueffl, H. H., Terenzi, A., Tolios, A., Mohr, T., Mathuber, M., Kryeziu, K., Jaunecker, C., Pirker, C., Keppler, B. K., Berger, W., Kowol, C. R., & Heffeter, P. (2023). A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo. Cancer Letters, 565, Artikel 216237. https://doi.org/10.1016/j.canlet.2023.216237

Kastner, A., Mendrina, T., Bachmann, F., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2023). Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs. Inorganic Chemistry Frontiers, 10(14), 4126-4138. https://doi.org/10.1039/d3qi00968h

Strasser, P., Montsch, B., Weiss, S., Sami, H., Kugler, C., Hager, S., Schueffl, H., Mader, R., Brüggemann, O., Kowol, C. R., Ogris, M., Heffeter, P., & Teasdale, I. (2023). Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo. Small, 19(22), Artikel 2300767. https://doi.org/10.1002/smll.202300767

Mendrina, T., Poetsch, I., Schueffl, H., Baier, D., Pirker, C., Ries, A., Keppler, B. K., Kowol, C. R., Gibson, D., Grusch, M., Berger, W., & Heffeter, P. (2023). Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands. Pharmaceutics, 15(2), Artikel 677. https://doi.org/10.3390/pharmaceutics15020677

Solta, A., Boettiger, K., Kovacs, I., Lang, C., Megyesfalvi, Z., Ferk, F., Misík, M., Hoetzenecker, K., Aigner, C., Kowol, C. R., Knasmueller, S., Grusch, M., Szeitz, B., Rezeli, M., Dome, B., & Schelch, K. (2023). Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair. Clinical Cancer Research, 29(22), 4644-4659. https://doi.org/10.1158/1078-0432.CCR-23-1795

Liu, X., Barth, M.-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Keppler, B. K., Gibson, D., & Weigand, W. (2022). Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity. Chemistry & Biodiversity, 19(10), Artikel e202200695. https://doi.org/10.1002/cbdv.202200695

Schwendenwein, A., Boettiger, K., Kovacs, I., Barany, N., Megyesfalvi, Z., Grusch, M., Kowol, C., Rezeli, M., Hoetzenecker, K., Dome, B., & Schelch, K. (2022). EP14.02-00 Cisplatin in Combination with Entinostat exerts Synergistic Antineoplastic Activity in Small Cell Lung Cancer. Journal of thoracic oncology, 17(9), S537-S537.

Posa, V., Stefanelli, A., Nunes, J. H. B., Hager, S., Mathuber, M., May, N., Berger, W., Keppler, B. K., Kowol, C. R., Enyedy, E. A., & Heffeter, P. (2022). Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance. Cancers, 14(18), Artikel 4455. https://doi.org/10.3390/cancers14184455

Falcone, E., Ritacca, A. G., Hager, S., Schueffl, H., Vileno, B., El Khoury, Y., Hellwig, P., Kowol, C. R., Heffeter, P., Sicilia, E., & Faller, P. (2022). Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH. Journal of the American Chemical Society, 144(32), 14758-14768. https://doi.org/10.1021/jacs.2c05355

Posa, V., Hajdu, B., Toth, G., Domotor, O., Kowol, C. R., Keppler, B. K., Spengler, G., Gyurcsik, B., & Enyedy, E. A. (2022). The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity. Journal of Inorganic Biochemistry, 231, Artikel 111786. https://doi.org/10.1016/j.jinorgbio.2022.111786

Fronik, P., Gutmann, M., Vician, P., Stojanovic, M., Kastner, A., Heffeter, P., Pirker, C., Keppler, B. K., Berger, W., & Kowol, C. R. (2022). A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance. Communications Chemistry, 5(1), Artikel 46. https://doi.org/10.1038/s42004-022-00661-z

Liu, X., Wenisch, D., Barth, M.-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Gibson, D., Keppler, B. K., & Weigand, W. (2022). Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions, 51(44), 16824-16835. https://doi.org/10.1039/d2dt02217f

Kandioller, W., Theiner, J., Keppler, B. K., & Kowol, C. R. (2021). Elemental analysis: an important purity control but prone to manipulations. Inorganic Chemistry Frontiers, 9(3), 412-416. https://doi.org/10.1039/d1qi01379c

Site-selectively functionalized Albumin with DFO*-maleimide for 89Zr-radiolabelling yields a metabolically stable nano-PET probe that enables late time-point imaging of tumors in a murine colorectal cancer model

Julia Kronberger (Vortragende*r), Theresa Balber (Autor*in), H. Schueffl (Autor*in), R. Wahrmann (Autor*in), Anja Federa (Autor*in), Thomas Wanek (Autor*in), Marie Brandt (Autor*in), Markus Mitterhauser (Autor*in), Christian Kowol (Autor*in), Thomas Mindt (Autor*in) & P. Heffeter (Autor*in)

19 Sept. 2024