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Assoz. Prof. Dr. Thomas Mindt, Privatdoz.

T: +43-1-4277-52690

thomas.mindt@univie.ac.at

https://mindt-group.univie.ac.at/

Sommersemester 2025

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270041 VO Medizinische Radiochemie 2 - Tracer Development - from Bench to Bed

270186 PR Praktikum Koordinationschemie

270192 PR Praktikum Radiopharmazeutische Chemie

530014 SE PhD / MSc Seminar Radiopharmazeutische Chemie

530015 SE Journal Club Radiopharmazeutische Chemie

Wintersemester 2024

270011 SE Erstellen der Bachelorarbeit A - Organische / Bioanorganische / Biologische / Biophysikalische Chemie

270012 PR Wahlfachpraktikum A (Bachelormodul) - Organische/Bioanorganische/Biologische/Biophysikalische Chemie

270040 VO Medizinische Radiochemie 1 - Radiopharmazeutische Chemie für die nuklearmedizinische Diagnostik und Therapie

270049 VO Einführung in die Chemie - Grundlagen - VO

270192 PR Praktikum Radiopharmazeutische Chemie

270315 VO Radioaktive Metalle in der Medizin

530014 SE PhD / MSc Seminar Radiopharmazeutische Chemie

530015 SE Journal Club Radiopharmazeutische Chemie

Federa, A., Schueffl, H., Minichmayr, I. K., Kastner, A., Kronberger, J., Mindt, T. L., Heffeter, P., & Kowol, C. R. (2025). Comparative Evaluation of Thiol- and Amine-Conjugating Moieties for Endogenous Albumin Binding after Intravenous Administration. ACS Pharmacology and Translational Science, 8(7), 2192-2203. https://doi.org/10.1021/acsptsci.5c00240

Kronberger, J., Balber, T., Schueffl, H., Wahrmann, R., Federa, A., Gradl, M., Brandt, M. R., Wanek, T., Mitterhauser, M., Kowol, C. R., Mindt, T. L., & Heffeter, P. (2025). Site-Selectively Functionalized Albumin with DFO*Maleimide for ⁸⁹Zr-Radiolabeling Yields a Metabolically Stable PET Probe that Enables Late Time-Point Tumor Imaging in Mice. Journal of Medicinal Chemistry, 68(12), 12925-12939. https://doi.org/10.1021/acs.jmedchem.5c00803

Feiner, I. V. J., Svatunek, D., Pressler, M., Demuth, T., Guarrochena, X., Sterba, J. H., Dorudi, S., Pichler, C., Denk, C., & Mindt, T. L. (2025). Towards DFO*¹²—Preliminary Results of a New Chelator for the Complexation of Actinium-225. Pharmaceutics, 17(3), Artikel 320. https://doi.org/10.3390/pharmaceutics17030320

Guarrochena, X., Anderla, M., Salomon, P., Feiner, I. V. J., Nock, B. A., Maina, T., & Mindt, T. L. (2025). Combination of the amide-to-triazole substitution strategy with alternative structural modifications for the metabolic stabilization of tumor-targeting, radiolabeled peptides. Journal of Peptide Science, 31(1), Artikel e3654. https://doi.org/10.1002/psc.3654

Guarrochena, X., Kanellopoulos, P., Stingeder, A., Rečnik, L. M., Feiner, I. V. J., Brandt, M., Kandioller, W., Maina, T., Nock, B. A., & Mindt, T. L. (2024). Amide-to-Triazole Switch in Somatostatin-14-Based Radioligands: Impact on Receptor Affinity and In Vivo Stability. Pharmaceutics, 16(3), Artikel 392. https://doi.org/10.3390/pharmaceutics16030392

Guarrochena, X., Kronberger, J., Tieber, M., Ciesielski, P., Mindt, T. L., & Feiner, I. V. J. (2024). Straightforward Synthesis of DFO* - An Octadentate Chelator for Zirconium-89. ChemMedChem, 19(3), Artikel e202300495. https://doi.org/10.1002/cmdc.202300495

Happl, B., Balber, T., Heffeter, P., Denk, C., Welch, J. M., Köster, U., Alliot, C., Bonraisin, A. C., Brandt, M., Haddad, F., Sterba, J. H., Kandioller, W., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2024). Synthesis and preclinical evaluation of BOLD-100 radiolabeled with ruthenium-97 and ruthenium-103. Dalton Transactions. Vorzeitige Online-Publikation. https://doi.org/10.1039/d4dt00118d

Schmitl, S., Raitanen, J., Witoszynskyj, S., Patronas, E. M., Nics, L., Ozenil, M., Weissenböck, V., Mindt, T. L., Hacker, M., Wadsak, W., Brandt, M. R., & Mitterhauser, M. (2023). Quality Assurance Investigations and Impurity Characterization during Upscaling of [¹⁷⁷Lu]Lu-PSMA^I&T. Molecules, 28(23), Artikel 7696. https://doi.org/10.3390/molecules28237696

Happl, B., Brandt, M., Balber, T., Benčurová, K., Talip, Z., Voegele, A., Heffeter, P., Kandioller, W., Van der Meulen, N. P., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2023). Synthesis and Preclinical Evaluation of Radiolabeled [¹⁰³Ru]BOLD-100. Pharmaceutics, 15(11), Artikel 2626. https://doi.org/10.3390/pharmaceutics15112626

Wang, Y., Felder, P. S., Mesdom, P., Blacque, O., Mindt, T. L., Cariou, K., & Gasser, G. (2023). Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy. ChemBioChem, 24(19), Artikel e202300467. https://doi.org/10.1002/cbic.202300467

Guarrochena, X., Kaudela, B., & Mindt, T. L. (2023). Automated solid-phase synthesis of metabolically stabilized triazolo-peptidomimetics. Journal of Peptide Science, 29(9), Artikel e3488. https://doi.org/10.1002/psc.3488

Wang, Y., Staudinger, J. N., Mindt, T. L., & Gasser, G. (2023). Theranostics with photodynamic therapy for personalized medicine: to see and to treat. Theranostics, 13(15), 5501-5544. https://doi.org/10.7150/thno.87363

Jouini, N., Cardinale, J., & Mindt, T. L. (2022). Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD-L1. ChemMedChem, 17(12), Artikel e202200091. https://doi.org/10.1002/cmdc.202200091

Rischka, L., Vraka, C., Pichler, V., Rasul, S., Nics, L., Gryglewski, G., Handschuh, P., Murgas, M., Godbersen, G. M., Silberbauer, L. R., Unterholzner, J., Wotawa, C., Haider, A., Ahmed, H., Schibli, R., Mindt, T., Mitterhauser, M., Wadsak, W., Hahn, A., ... Ametamey, S. M. (2022). First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-D-aspartate Receptor with (R)-C-11-Me-NB1. Journal of Nuclear Medicine, 63(6), 936-941. https://doi.org/10.2967/jnumed.121.262427

Giammei, C., Jouini, N., Brandt, M. R., Frey, S., Mindt, T. L., & Cardinale, J. (2022). Unexpected transformation of n.c.a. [ ¹¹¹In]InCl ₃ in stock solutions into an unreactive [ ¹¹¹In]In-species. Applied Radiation and Isotopes, 180, Artikel 110037. https://doi.org/10.1016/j.apradiso.2021.110037

Rischka, L., Murgaš, M., Pichler, V., Vraka, C., Rausch, I., Winkler, D., Nics, L., Rasul, S., Silberbauer, L. R., Reed, M. B., Godbersen, G. M., Unterholzner, J., Handschuh, P., Gryglewski, G., Mindt, T., Mitterhauser, M., Hahn, A., Ametamey, S. M., Wadsak, W., ... Hacker, M. (2022). Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[¹¹C]Me-NB1. EJNMMI Research, 12(1), Artikel 53. https://doi.org/10.1186/s13550-022-00925-8

Klasen, B., Lemcke, D., Mindt, T. L., Gasser, G., & Roesch, F. (2021). Development and in vitro evaluation of new bifunctional ⁸⁹Zr-chelators based on the 6-amino-1,4-diazepane scaffold for immuno-PET applications. Nuclear Medicine and Biology, 102-103, 12-23. https://doi.org/10.1016/j.nucmedbio.2021.06.007

Rischka, L., Vraka, C., Pichler, V., Rasul, S., Nics, L., Gryglewski, G., Handschuh, P., Murgas, M., Godbersen, G. M., Silberbauer, L. R., Unterholzner, J., Wotawa, C., Haider, A., Ahmed, H., Schibli, R., Mindt, T., Mitterhauser, M., Wadsak, W., Hahn, A., ... Ametamey, S. M. (2021). First-in-human mapping of the GluN2B subunits of the N-methyl-D-aspartate receptor using (R)-[(11)Cc]Me-NB1 and PET. European Journal of Nuclear Medicine and Molecular Imaging, 48(SUPPL 1), 296.

Feiner, I. V. J., Brandt, M., Cowell, J., Demuth, T., Vugts, D., Gasser, G., & Mindt, T. L. (2021). The Race for Hydroxamate-Based Zirconium-89 Chelators. Cancers, 13(17), Artikel 4466. https://doi.org/10.3390/cancers13174466

Grob, N. M., Schibli, R., Behe, M., & Mindt, T. L. (2021). Improved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin Lu-177-PP-F11N. Cancers, 13(11), Artikel 2629. https://doi.org/10.3390/cancers13112629